The Tim Ferriss Show

James Nestor is a science journalist and the author of the international bestseller Breath: The New Science of a Lost Art [https://www.amazon.com/Breath-New-Science-Lost-Art/dp/0735213615/?tag=offsitoftimfe-20], with more than three million copies sold in 44 languages. This episode is brought to you by: Helix Sleep [https://helixsleep.com/tim] premium mattresses: https://HelixSleep.com/Tim [https://helixsleep.com/tim] (27% off all mattress orders) Momentous [https://livemomentous.com/Tim] high-quality creatine for cognitive and muscular support: https://livemomentous.com/Tim [https://livemomentous.com/Tim] (Code TIM for up to 35% off.) AG1 [https://drinkag1.com/Tim] all-in-one nutritional supplement: https://DrinkAG1.com/Tim [https://drinkag1.com/Tim] (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.) Timestamps: [00:00:00] Start. [00:01:37] Why I waited years to interview James about Breath. [00:02:35] Maurice Daubard: The mysterious 90-year-old who preceded Wim Hof. [00:05:01] Tummo breathing: Ancient Bon Buddhist heat generation. [00:08:13] James’ personal breathwork practice and the Wim Hof method (with warnings). [00:09:25] How breathwork cured James’ chronic respiratory issues. [00:11:46] Sudarshan Kriya: The weekend workshop that changed everything. [00:16:56] My nine-minute breath hold experiment (hyperbaric chamber edition). [00:18:57] Post-book revelations and angry doctors’ offices. [00:20:41] The ADHD-breathing connection: A controversial Venn diagram. [00:22:00] DIY breathing assessments for kids. [00:25:55] Mouth tape: From hostage situations to sleep optimization. [00:28:48] James’ seven-year mouth taping commitment. [00:31:14] CO2 levels: Your LEED-certified hotel is suffocating you. [00:36:50] Monitoring CO2 with the Aranet4 and building a CO2 database. [00:39:51] James’ travel kit: Red lights, granny packs, and a Soviet-era PEMF device. [00:51:59] In Weirdville, eyes sing The Body Electric. [00:52:58] The supplements included in David’s granny packs. [00:54:16] Natto vs. nattokinase. [00:56:18] Athletes and breathing: The BOLT score explained. [01:03:25] LeBron James’ alternate nostril breathing and diaphragmatic dysfunction. [01:04:47] Inspiratory muscle training and the back soreness warning. [01:08:47] The Relaxator: An adult breathing pacifier for focus. [01:12:54] San Francisco Writers Grotto and the trustafarian invasion. [01:16:10] Writer’s block: A convenient excuse for hobbyists. [01:19:04] Cutting the corporate cord: James’ visceral “I quit” moment. [01:23:25] The freediving story that launched a book deal. [01:25:41] Deep‘s disappointing launch and publisher betrayal. [01:28:10] Breath: From 290,000 words to 85,000 in a house in the woods. [01:31:51] Finding the skeleton: The Stanford experiment as through-line. [01:35:44] Prayer and coherent breathing: The 5.5-second secret. [01:38:44] James’ critique of breathwork culture and barriers to entry. [01:41:07] Sleep optimization: SnoreLab, side sleeping, and incline bed therapy. [01:44:56] Parting thoughts and where to find James and free breathing protocols. * Show notes for this episode: https://tim.blog/2025/09/30/james-nestor-breath/ [https://tim.blog/2025/09/30/james-nestor-breath/] For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. Follow Tim: Twitter: twitter.com/tferriss [https://twitter.com/tferriss]  Instagram: instagram.com/timferriss [https://instagram.com/timferriss/] YouTube: youtube.com/timferriss [https://www.youtube.com/timferriss] Facebook: facebook.com/timferriss [https://www.facebook.com/TimFerriss/]  LinkedIn: linkedin.com/in/timferriss [http://linkedin.com/in/timferriss] See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

David Senra is the host of the Founders [https://www.youtube.com/@founderspodcast1/videos] podcast. For the past nine years, David has intensely studied the life and work of hundreds of history’s greatest entrepreneurs. His new podcast, David Senra [https://www.davidsenra.com/], showcases conversations with the best-of-the-best living founders and extreme winners. This episode is brought to you by: Cresset [https://cressetcapital.com/tim] family office services for CEOs, founders, and entrepreneurs Our Place’s Titanium Always Pan® Pro [https://fromourplace.com/tim] using nonstick technology that’s coating-free and made without PFAS, otherwise known as “Forever Chemicals” AG1 [https://drinkag1.com/tim] all-in-one nutritional supplement Timestamps: [00:00:00] Who is David Senra? [00:01:11] Brad Jacobs: Roll-up king and positive-driven billionaire founder. [00:02:26] Rare positive archetypes: Ed Thorp, Sol Price, Brunello Cucinelli. [00:06:04] Michael Dell as another exception; fear of failure and motivation. [00:06:47] Negative self-talk, excellence, and its ripple effects. [00:08:26] Jensen Huang story: “Why do you suck so much?” [00:08:54] Inspiration from Dan Carlin’s Hardcore History. [00:10:00] Derek Sivers: unconventional, philosophical entrepreneur. [00:11:04] Learning equals behavior change, not memorization. [00:11:48] Jeremy Giffon insight: biographies as substitute mentors. [00:12:37] Reading biographies as one-sided conversations. [00:13:16] The chain of influence. [00:14:09] Podcasting as “relationships at scale.” [00:14:28] Coping with trauma and breaking cycles. [00:20:18] Note-taking process: books, Post-its, ruler, Readwise. [00:29:27] OCD tendencies and love of doing things the hard way. [00:31:04] Comparing our reading/re-reading workflows. [00:35:04] A family falling out and the randomness of student housing. [00:38:58] David’s introduction to my work during his MySpace-era college years. [00:40:07] Podcasting influences: Jocko Willink, Kevin Rose’s Elon Musk interview. [00:44:14] Five-and-a-half years of obscurity before breakthrough. [00:46:50] Graphtreon and experiments with subscription models. [00:49:25] Patrick O’Shaughnessy’s endorsement sparks growth. [00:51:23] Sam Hinkie and Patrick connections fuel momentum. [00:52:19] Transition to ads and joining Patrick’s network. [00:55:17] Edwin Land: patron saint of founders and Steve Jobs’ influence. [00:57:02] Lessons from Sam Zell, Jay Pritzker, and William Zeckendorf. [00:58:48] Need a generous, well-connected person? You can’t go wrong with Rick Gerson. [01:03:04] Edwin Land’s philosophies: Differentiation and doing to excess. [01:04:30] Entrepreneurial archetypes and conflicting advice. [01:06:00] Daniel Ek as an alternative founder archetype and mentor. [01:10:59] Further founder archetypes and contrasts. [01:13:41] What is an anti-business billionaire? [01:19:55] Advice from “shark” Michael Ovitz about the value of truth in one’s inner circle. [01:22:30] The hands-on approach of practical founders who live for the love of their business. [01:23:28] Doing one thing relentlessly. [01:23:51] “This can’t be my life” as a powerful motivator. [01:26:57] Low introspection as a common trait among founders — and its implications about human nature. [01:30:15] Robert Caro: The only writer David believes should be allowed to write thousand-page biographies. [01:32:40] James Dyson’s persistence vs. the risk of blind stubbornness. [01:34:22] Todd Graves (Raising Cane’s) as an example of relentless focus on one idea. [01:35:41] Separating fact from fiction in biographies/histories. [01:41:55] Considering trainable vs. non-trainable attributes in potential role models. [01:46:11] Perusing Charlie Munger’s library. [01:49:35] Dealmaking lessons on Eddie Lampert’s superyacht. [01:55:34] The smartest person David knows. [01:56:55] David’s obsessive craftsman approach to podcast creation. [01:58:51] Why David decided to begin a second podcast. [02:01:21] The economics of trust. [02:03:40] The benefits of cultivating a purposeful aloofness about current events. [02:07:11] Using the pulpit of publicity for good, not evil. [02:09:57] New show frequency/dynamic and how David plans to balance the burden of running two shows. [02:13:30] Teamwork with essence of turtle. [02:15:40] Adapting the Rockefeller “secret allies” strategy to podcasting. [02:17:56] Chris Hutchins: The mad scientist of podcasting? [02:18:30] Working with Rob Mohr and Andrew Huberman of SciComm. [02:20:54] Why David focuses on 24-hour cycles over long-term planning. [02:24:54] Does David worry the extra workload will disrupt his lifestyle? [02:30:18] What makes one potential guest more interesting to David than another? [02:34:34] Making an impact vs. happiness. [02:36:32] Playing the status game when your heart’s not in it is for suckers. [02:44:23] Travel observations and the rarity of truly unique experiences. [02:46:26] Books as philosophical operating systems. [02:48:39] Parting thoughts. See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Pablos Holman is a hacker and inventor and the author of Deep Future: Creating Technology that Matters [https://www.amazon.com/Deep-Future-Creating-Technology-Matters/dp/B0F23CLXZP/?tag=offsitoftimfe-20], the indispensable guide to deep tech. Previously, Pablos worked on spaceships at Blue Origin and helped build The Intellectual Ventures Lab [https://www.intellectualventures.com/what-we-do/iv-lab] to invent a wide variety of breakthroughs. Pablos also hosts the Deep Future Podcast [https://deepfuture.tech/podcast-index/] and is managing partner at Deep Future [https://deepfuture.tech/]. This episode is brought to you by: Cresset [https://cressetcapital.com/tim] prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/tim [https://cressetcapital.com/tim] Maui Nui Venison [https://mauinuivenison.com/lp/tim], delicious, nutrient-dense, and responsible red meat: https://mauinuivenison.com/lp/tim [https://mauinuivenison.com/lp/tim] AG1 [https://drinkag1.com/tim] all-in-one nutritional supplement: https://drinkag1.com/tim [https://drinkag1.com/tim] Timestamps: * [00:00:00] Start. * [00:02:12] The first time I witnessed Pablos’ digital sleight of hand. * [00:04:33] How did Pablos become what he considers to be a hacker? * [00:08:04] The off-label mindset that makes a good hacker (like Samy Kamkar) great. * [00:17:07] The magic of Rodney Mullen. * [00:20:28] How Eric Johanson and Pablos gave life to adorable password thief Hackerbot. * [00:23:44] Hacker self-defense and the zero-click exploit market. * [00:27:11] International pockets of hacker density. * [00:30:13] Conventions where modern hackers congregate. * [00:30:48] Why, in geopolitics, technology is a game lost by the non-players. * [00:33:05] The case to rally behind new nuclear power. * [00:36:54] Sequencing priorities so the US can remain technologically competitive. * [00:44:49] Evaluating risk and reward in deep tech investment. * [00:50:40] Shoring up the shape of shipping. * [00:56:59] How Pablos gained his name and famous frames. * [00:58:48] Pablos is a possible-ist. * [00:59:45] What makes Pablos an attractive hire for the world’s richest people? * [01:02:06] From Silicon Valley to Seattle: the Blue Origin origin story. * [01:08:55] Why Pablos prevails over his M-dash peers. * [01:11:41] Zero Effect and WarGames: The only movies that matter? * [01:15:58] A major security malfunction exploited by Major Malfunction. * [01:18:30] The enigmatic Neal Stephenson. * [01:19:38] Long-form lessons gleaned from Jeff Bezos and the Blue Origin mission. * [01:27:15] For solving the world’s problems, communities are crucial. * [01:31:03] Newlab PSYOPS. * [01:34:44] AI and the ripple effects of China’s engineering-minded vs. America’s attorney-heavy leadership. * [01:48:20] Unearthing like-minded inventors and innovators. * [01:50:42] How Pablos learned salsa dancing via aikido vs. my own tango experience. * [02:08:27] Why you should invest or get involved in deep tech. * [02:14:45] Clearing up fusion confusion. * [02:21:17] Making progress happen is a team effort. * [02:24:19] Parting thoughts. * For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. Follow Tim: Twitter: twitter.com/tferriss [https://twitter.com/tferriss]  Instagram: instagram.com/timferriss [https://instagram.com/timferriss/] YouTube: youtube.com/timferriss [https://www.youtube.com/timferriss] Facebook: facebook.com/timferriss [https://www.facebook.com/TimFerriss/]  LinkedIn: linkedin.com/in/timferriss [http://linkedin.com/in/timferriss] Past guests on The Tim Ferriss Show [http://tim.blog/podcast] include Jerry Seinfeld [https://tim.blog/2020/12/08/jerry-seinfeld/], Hugh Jackman [https://tim.blog/2020/06/26/hugh-jackman/], Dr. Jane Goodall [https://tim.blog/2020/04/16/jane-goodall/], LeBron James [https://tim.blog/2018/11/27/lebron-james-mike-mancias/], Kevin Hart [https://tim.blog/2020/05/20/kevin-hart/], Doris Kearns Goodwin [https://tim.blog/2018/09/07/doris-kearns-goodwin-leadership/], Jamie Foxx [https://tim.blog/2015/12/06/jamie-foxx/], Matthew McConaughey [https://tim.blog/2020/10/19/matthew-mcconaughey/], Esther Perel [https://tim.blog/2017/05/21/esther-perel/], Elizabeth Gilbert [https://tim.blog/2020/05/08/elizabeth-gilbert/], Terry Crews [https://tim.blog/2017/12/20/terry-crews-how-to-have-do-and-be-all-you-want/], Sia [https://tim.blog/2020/08/12/sia/], Yuval Noah Harari [https://tim.blog/2020/10/27/yuval-noah-harari/], Malcolm Gladwell [https://tim.blog/2016/06/21/malcolm-gladwell/], Madeleine Albright [https://tim.blog/2020/05/27/secretary-madeleine-albright/], Cheryl Strayed [https://tim.blog/2017/03/30/cheryl-strayed/], Jim Collins [https://tim.blog/2019/02/18/jim-collins/], Mary Karr, [https://tim.blog/2020/11/11/mary-karr/] Maria Popova [https://tim.blog/2014/10/21/brain-pickings/], Sam Harris [https://tim.blog/2020/05/15/sam-harris-2/], Michael Phelps [https://tim.blog/2021/01/21/michael-phelps-grant-hackett/], Bob Iger [https://tim.blog/2020/01/16/bob-iger/], Edward Norton [https://tim.blog/2019/10/31/edward-norton-motherless-brooklyn/], Arnold Schwarzenegger [https://tim.blog/2015/02/02/arnold-schwarzenegger/], Neil Strauss [https://tim.blog/2014/06/24/neil-strauss/], Ken Burns [https://tim.blog/2019/09/12/ken-burns/], Maria Sharapova [https://tim.blog/2017/08/26/maria-sharapova/], Marc Andreessen [https://tim.blog/2016/05/29/marc-andreessen/], Neil Gaiman [https://tim.blog/2019/03/28/neil-gaiman/], Neil de Grasse Tyson [https://tim.blog/2019/10/03/neil-degrasse-tyson/], Jocko Willink [https://tim.blog/2016/09/21/jocko-willink-on-discipline-leadership-and-overcoming-doubt/], Daniel Ek [https://tim.blog/2020/12/03/daniel-ek/], Kelly Slater [https://tim.blog/2020/09/08/kelly-slater/], Dr. Peter Attia [https://tim.blog/2019/11/27/peter-attia-fasting-metformin-longevity/], Seth Godin [https://tim.blog/2016/02/10/seth-godin/], Howard Marks [https://tim.blog/2018/09/25/howard-marks/], Dr. Brené Brown [https://tim.blog/2020/02/06/brene-brown-striving-self-acceptance-saving-marriages/], Eric Schmidt [https://tim.blog/2019/04/09/eric-schmidt/], Michael Lewis [https://tim.blog/2020/05/01/michael-lewis/], Joe Gebbia [https://tim.blog/2018/03/08/joe-gebbia-co-founder-of-airbnb/], Michael Pollan [https://tim.blog/2018/05/06/michael-pollan-how-to-change-your-mind/], Dr. Jordan Peterson [https://tim.blog/2021/03/01/jordan-peterson/], Vince Vaughn [https://tim.blog/2017/05/31/vince-vaughn/], Brian Koppelman [https://tim.blog/2020/04/23/brian-koppelman/], Ramit Sethi [https://tim.blog/2019/05/07/ramit-sethi/], Dax Shepard [https://tim.blog/2020/11/18/dax-shepard/], Tony Robbins [https://tim.blog/2014/10/15/money-master-the-game/], Jim Dethmer [https://tim.blog/2020/05/18/jim-dethmer/], Dan Harris [https://tim.blog/2020/11/19/dan-harris/], Ray Dalio [https://tim.blog/2017/09/13/ray-dalio/], Naval Ravikant [https://tim.blog/2015/08/18/the-evolutionary-angel-naval-ravikant/], Vitalik Buterin [https://tim.blog/2021/03/08/vitalik-buterin-naval-ravikant/], Elizabeth Lesser [https://tim.blog/2021/03/16/elizabeth-lesser/], Amanda Palmer [https://tim.blog/2019/04/18/amanda-palmer-2/], Katie Haun [https://tim.blog/2021/02/18/katie-haun/], Sir Richard Branson [https://tim.blog/2017/10/09/richard-branson/], Chuck Palahniuk [https://tim.blog/2020/09/02/chuck-palahniuk/], Arianna Huffington [https://tim.blog/2017/10/18/arianna-huffington/], Reid Hoffman [https://tim.blog/2015/08/31/the-oracle-of-silicon-valley-reid-hoffman-plus-michael-mccullough/], Bill Burr [https://tim.blog/2017/09/17/bill-burr/], Whitney Cummings [https://tim.blog/2015/06/26/whitney-cummings/], Rick Rubin [https://tim.blog/2015/05/15/rick-rubin/], Dr. Vivek Murthy [https://tim.blog/2020/03/26/vivek-murthy/], Darren Aronofsky [https://tim.blog/2017/09/09/darren-aronofsky/], Margaret Atwood [https://tim.blog/2022/02/22/margaret-atwood/], Mark Zuckerberg [https://tim.blog/2022/03/24/mark-zuckerberg/], Peter Thiel [https://tim.blog/2014/09/09/peter-thiel/], Dr. Gabor Maté [https://tim.blog/2018/02/20/gabor-mate/], Anne Lamott [https://tim.blog/2021/07/09/anne-lamott/], Sarah Silverman [https://tim.blog/2022/01/12/sarah-silverman/], Dr. Andrew Huberman [https://tim.blog/2021/07/06/andrew-huberman/], and many more. See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

This episode is a solo Q&A session where I answer a bunch of questions. We covered a ton of ground, from personal health protocols to professional frameworks and creative projects.  This episode is brought to you by: Eight Sleep Pod Cover 5 [https://www.eightsleep.com/tim/] sleeping solution for dynamic cooling and heating: EightSleep.com/Tim [https://www.eightsleep.com/tim/] (use code TIM to get $350 off your very own Pod 5 Ultra.) Monarch Money [https://www.monarchmoney.com/tim] track, budget, plan, and do more with your money: MonarchMoney.com/Tim [https://www.monarchmoney.com/tim] (50% off your first year at monarchmoney.com with code TIM) Shopify [https://shopify.com/tim] global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim [https://shopify.com/tim] (one-dollar-per-month trial period) Timestamps: [00:00:00] Start [00:06:00] Coyote retail distribution challenges and data gathering. [00:09:12] Elbow surgery recovery: sequencing, decongestion, Marc Pro device, peptides, BFR training. [00:16:14] California vs. Austin for builders, mechanical engineers, and tech startups. [00:19:06] Using AI for medical advice workflow (and cross-referencing with professionals). [00:23:51] Current supplement regimen and PAGG/AGG status. [00:31:54] California vs. Texas considerations for aspiring parents. [00:32:48] Saying "No" to good things for "Hell, yes" moments. [00:34:34] Philanthropy lessons learned since starting Saisei Foundation. [00:37:45] Something I've changed my mind about recently: intermittent fasting. [00:42:44] Precious items from childhood I still keep: D&D relics and marine biology books. [00:43:03] Bucket list hike: Glacier National Park. [00:43:42] How the catalytic chaos of publishing The 4-Hour Chef led to launching this podcast. [00:45:52] Bringing delight vs. sixth-gear, high-performance focus. [00:49:05] Thoughts on extended human fasting research from the Soviet era. [00:52:58] Most magical New Mexico experience: Mountain Cloud Zen Center meditation retreat. [00:53:22] Meta skills for the AI era: Hyper-adaptability and world-class learning. [00:54:01] The (real and ideal) future of CØCKPUNCH/Legends of Varlata. [00:59:47] Competitive chess training enhancement: glucose management, intermittent fasting, MCT oil. [01:06:31] Behind-the-scenes projects: Fusion, algae feed additives, meat alternatives. [01:08:32] Countries I wish I had visited earlier, and places I'd still like to see. [01:11:06] "Not yet" vs. "No" in early growth phases. [01:14:14] Post Coyote, do I have any future games in the works? [01:14:46] Over-ear vs. in-ear headphones for podcasting. [01:15:16] What's the uncrowded channel right now? [01:16:17] Recommendations for Dr. Mindy Pelz. [01:16:58] Robert Rodriguez and project juggling. [01:17:24] Fast neutron reactors and the Bugatti of ketones. [01:19:05] Extended family outings and Mahonk Mountain House. [01:20:31] NO BOOK meetup plans? [01:20:54] Parting thoughts. * For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. Follow Tim: Twitter: twitter.com/tferriss [https://twitter.com/tferriss]  Instagram: instagram.com/timferriss [https://instagram.com/timferriss/] YouTube: youtube.com/timferriss [https://www.youtube.com/timferriss] Facebook: facebook.com/timferriss [https://www.facebook.com/TimFerriss/]  LinkedIn: linkedin.com/in/timferriss [http://linkedin.com/in/timferriss] Past guests on The Tim Ferriss Show [http://tim.blog/podcast] include Jerry Seinfeld [https://tim.blog/2020/12/08/jerry-seinfeld/], Hugh Jackman [https://tim.blog/2020/06/26/hugh-jackman/], Dr. Jane Goodall [https://tim.blog/2020/04/16/jane-goodall/], LeBron James [https://tim.blog/2018/11/27/lebron-james-mike-mancias/], Kevin Hart [https://tim.blog/2020/05/20/kevin-hart/], Doris Kearns Goodwin [https://tim.blog/2018/09/07/doris-kearns-goodwin-leadership/], Jamie Foxx [https://tim.blog/2015/12/06/jamie-foxx/], Matthew McConaughey [https://tim.blog/2020/10/19/matthew-mcconaughey/], Esther Perel [https://tim.blog/2017/05/21/esther-perel/], Elizabeth Gilbert [https://tim.blog/2020/05/08/elizabeth-gilbert/], Terry Crews [https://tim.blog/2017/12/20/terry-crews-how-to-have-do-and-be-all-you-want/], Sia [https://tim.blog/2020/08/12/sia/], Yuval Noah Harari [https://tim.blog/2020/10/27/yuval-noah-harari/], Malcolm Gladwell [https://tim.blog/2016/06/21/malcolm-gladwell/], Madeleine Albright [https://tim.blog/2020/05/27/secretary-madeleine-albright/], Cheryl Strayed [https://tim.blog/2017/03/30/cheryl-strayed/], Jim Collins [https://tim.blog/2019/02/18/jim-collins/], Mary Karr, [https://tim.blog/2020/11/11/mary-karr/] Maria Popova [https://tim.blog/2014/10/21/brain-pickings/], Sam Harris [https://tim.blog/2020/05/15/sam-harris-2/], Michael Phelps [https://tim.blog/2021/01/21/michael-phelps-grant-hackett/], Bob Iger [https://tim.blog/2020/01/16/bob-iger/], Edward Norton [https://tim.blog/2019/10/31/edward-norton-motherless-brooklyn/], Arnold Schwarzenegger 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Dr. Dominic D’Agostino (@DominicDAgosti2 [https://x.com/DominicDAgosti2]) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by: Helix Sleep [https://helixsleep.com/tim] premium mattresses: https://HelixSleep.com/Tim [https://helixsleep.com/tim] (27% off all mattress orders) Momentous [https://livemomentous.com/tim] high-quality creatine: https://livemomentous.com/tim [https://livemomentous.com/tim] (code TIM for up to 35% off) AG1 [https://drinkag1.com/Tim] all-in-one nutritional supplement: https://DrinkAG1.com/Tim [https://drinkag1.com/Tim] (1-year supply of Vitamin D plus 5 free AG1 travel packs) Timestamps: [00:00:00] Start. [00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention. [00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements. [00:18:18] A mechanisms overview for Alzheimer's/dementia. [00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key. [00:22:04] How to measure ketones and GKI. [00:23:00] Fasting vs. ketogenic diet. [00:24:18] There's nothing fishy about sardine fasting. [00:28:32] My hiatal hernia discovery and increased cancer risk concerns. [00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk. [00:31:57] Glucose tolerance testing revelations and CGM importance. [00:31:57] Upgrading the metabolic machinery through keto without getting bored. [00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption. [00:43:42] Dom's day-to-day diet regimen. [00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements. [00:51:30] Supplementing for sleep disruption while fasting. [00:55:41] Why Dom doesn't have misgivings about melatonin. [00:59:15] Shingles prevention through fasting protocols. [01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic. [01:03:54] Dom at 50-something: Current meal timing and composition. [01:05:57] Blue zone observations: Greek and Sardinian longevity habits. [01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio. [01:15:18] Ketone metabolic therapy for cancer. [01:18:15] The metabolic psychiatry revolution. [01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers. [01:28:27] Metformin vs. berberine. [01:31:43] The low-dose neuroprotective potential of GLP-1 drugs. [01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health. [01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS. [01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin. [01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts. * Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/ For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. Follow Tim: Twitter: twitter.com/tferriss [https://twitter.com/tferriss]  Instagram: instagram.com/timferriss [https://instagram.com/timferriss/] YouTube: youtube.com/timferriss [https://www.youtube.com/timferriss] Facebook: facebook.com/timferriss [https://www.facebook.com/TimFerriss/]  LinkedIn: linkedin.com/in/timferriss [http://linkedin.com/in/timferriss] See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].