Weight and Metabolism

Trauma and ACE

Trauma doesn't just live in memory. It lives in the body — in a nervous system that never got the signal that it was safe to stand down.  You may have come to Dr. Deepti Sharma looking for answers about your weight, your energy, your hormones, or your metabolic health. But in Part 2 of this series, she's going to ask you to look a little further back. In this she picks up where the ACEs conversation left off and goes deeper into what trauma actually does to human physiology. From the way chronic stress hormones reshape the brain and gut, to the downstream effects on inflammation, metabolism, and chronic disease risk — this episode makes the invisible visible. Dr. Sharma explains how unresolved trauma can look like anxiety, emotional eating, fatigue, autoimmune flares, or a body that simply won't respond the way it "should" — and why none of that is a character flaw. She brings together neuroscience, the metabolic science, and the human experience into a single cohesive picture that is as clinically grounded as it is compassionate. Whether you're a patient trying to understand why your health feels so complicated, or a provider looking to deepen your trauma-informed lens, this episode gives you the framework to see it clearly. Because for many people, the missing piece isn't a lab value or a medication dose — it's an understanding of how their history shaped their biology.

ACE - Adverse Childhood Experiences and their impact on our health

In this foundational episode, Dr. Sharma — triple board-certified physician, certified Menopause Practitioner, and certified life coach — unpacks adverse childhood experiences from the ground up. What counts as an ACE. Why the metabolic consequences of early trauma can look like willpower problems, lifestyle failures, or "unexplained" disease — and why that framing is wrong. ACEs aren't just a childhood story. They reshape the stress response, dysregulate the HPA axis, and leave a biological fingerprint that shows up decades later as chronic disease, metabolic dysfunction, and yes — obesity. In this broad overview episode, Dr. Sharma breaks down what ACEs actually are, how they wire the nervous system for survival in ways that can work against us in adulthood, and why understanding this science isn't about blame — it's about finally having a framework that makes sense of so much suffering. Whether you're a patient trying to understand your own health history, or a clinician looking to bring more trauma-informed care into your practice, this episode meets you where you are. This is the foundation. Stay tuned — the next episode goes deeper into what we can actually do with this knowledge.

Contributing Factors to Obesity — Genetics, Epigenetics, Hormones, and Set Point Theory

In the next few episodes, I want to talk about the contributing factors or causes of obesity in detail. The number one thing is genetics. Genetic predisposition plays a foundational role, influencing metabolic processes, fat storage, and appetite regulation. However, genetics alone do not dictate outcomes. This introduces the concept of epigenetics, which refers to changes in gene expression due to environmental factors like diet, stress, and even prenatal influences. Think of genetics as the blueprint or instruction manual. Epigenetics is like a light switch that turns certain genes on or off. Dysfunction within neurohormonal pathways disrupts the delicate balance of hunger and satiety signals, metabolic rate, and fat distribution. Hormones like leptin, ghrelin, insulin, and cortisol interact in ways that can drive excessive weight gain when dysregulated. This brings us to the set point theory of body fat mass, which suggests that our body has a predetermined range of fat mass or weight that it naturally tries to defend. Fat mass is a physiologically regulated phenotype, tightly regulated just like body temperature and pH. Obesity results from abnormal regulation of body fat mass, meaning changes in underlying biology lead the body to an elevated fat mass. This is why obesity is a disease. When you lose weight, your body activates mechanisms to regain it, such as increasing hunger, reducing energy expenditure, and increasing cravings. Adipose tissue is not just a blob of yellow cushiony tissue. It's a powerful and dynamic organ producing over 600 adipokines or hormones, including leptin, adiponectin, resistin, and TNF-alpha. They drive hormone regulation and dysregulation, contributing to metabolic processes involved in appetite regulation, insulin sensitivity, inflammation, and the pathogenesis of heart disease, chronic disease, and cancer. Leptin is the satiety hormone that helps us feel full. However, too much leptin leads to leptin resistance, where the brain becomes resistant to the hormone's message, resulting in reduced satiety, overeating, and weight gain. Research shows that calorie-dense processed foods impair the brain's leptin signaling. Insulin is another key player. When we eat calorie-dense meals, glucose rises rapidly, making the pancreas pump out insulin. Over time, with too much glucose and fat accumulating, insulin doesn't work as well, resulting in insulin resistance, the precursor to pre-diabetes and type 2 diabetes. Insulin is an anabolic hormone that signals the body to store fat and increase hunger. Other important gut hormones include ghrelin (the hunger hormone), GLP-1 and GIP (satiety hormones targeted by medications like Ozempic, Wegovy, Mounjaro, and Zepbound), glucagon (maintains blood glucose levels during fasting), and amylin (suppresses appetite and slows gastric emptying). 🌐 Learn more at weightandmetabolism.com [https://www.weightandmetabolism.com]

How Your Weight Impacts Your Health

Let's talk about what obesity actually does to your body — not to shame or scare you, but so you understand what's really at stake. In this episode, I walk through the hard science: obesity is an independent risk factor for sudden and premature death. All-cause mortality increases progressively with higher BMI, especially once you cross a BMI of 30. In the U.S. alone, obesity contributes to an estimated 300,000 deaths annually. For those with severe obesity (BMI over 40), life expectancy can be reduced by 5 to 20 years. But it's not just about lifespan — it's about how you live those years. Obesity affects every single organ system and is a central driver in the development of chronic diseases and 13 different types of cancer. We cover it all: * Cardiovascular disease: hypertension, coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral vascular disease * Metabolic disorders: type 2 diabetes, dyslipidemia, metabolic syndrome * Respiratory issues: asthma, sleep apnea, hypoventilation syndrome * Gastrointestinal & liver disease: gallstones, reflux, IBS, fatty liver disease * Musculoskeletal problems: osteoarthritis, chronic pain, mobility issues, increased fall risk * Cancer: 13 confirmed obesity-related cancers, including colorectal, breast, endometrial, pancreatic, and more * Reproductive health: fertility issues, PCOS, erectile dysfunction, pregnancy complications * Mental health: depression, anxiety, body image struggles, stigma, and discrimination in healthcare This episode isn't meant to overwhelm you. It's meant to help you see why addressing obesity isn't about vanity — it's about protecting your health, your quality of life, and your future. 🌐 Learn more at weightandmetabolism.com [https://www.weightandmetabolism.com]

The Obesity Epidemic by the Numbers

Let's talk about just how big this problem really is — because the stats are staggering. In 2022, 1 in 8 people globally were diagnosed with obesity. Adult obesity has more than doubled since 1990. Adolescent obesity? It's quadrupled. Here in the U.S., the numbers are even more alarming: more than 2 in 5 adults (42.4%) have obesity, and 1 in 11 adults have severe obesity. Among children and adolescents aged 2-19, nearly 1 in 5 (19.3%) have obesity, and 6.1% have severe obesity. If you include the overweight category, nearly 75% of U.S. adults are affected. And here's the kicker: despite decades of education about healthy eating and exercise, the numbers keep climbing. In fact, no country in the world has made significant progress in tackling obesity over the last 40 years. So what are we doing wrong? Why is this epidemic continuing to grow despite everything we know? That's the question we need to answer — and it starts with understanding that this isn't about individual failure. It's systemic. It's biological. It's environmental. And it requires a complete shift in how we approach prevention and treatment. In the next episode, we'll dive into the consequences of not addressing obesity — and why taking action matters now more than ever. 🌐 Learn more at weightandmetabolism.com [https://www.weightandmetabolism.com]