Beyond the Symptoms | An Expert Interview Series by LUF | Live UTI Free

ETAP Trial: Extended Antibiotic Treatment for Chronic UTI | Dr. Kiren Gill and Dr. Harry Horsley with Live UTI Free (LUF)

A clinical trial that actually defines chronic UTI and tests a treatment protocol designed around it has been a long time coming. In this episode of the Live UTI Free podcast, host Melissa Kramer sits down with Dr. Kiran Gill and Dr. Harry Horsley to talk through the ETAP trial, a new UK-based phase 2 randomised controlled trial investigating extended full-dose antibiotics combined with methenamine hippurate (Hiprex) for chronic UTI. Dr. Kiran Gill is a consultant urogynaecologist at the Whittington Hospital and a clinical academic at University College London, and co-chief investigator on ETAP alongside Professor Rajvinder Khasriya. Dr. Harry Horsley is principal investigator and scientific lead, and co-leads the Bladder Infection and Immunity Group (BIIG) at UCL, where he has been researching recurrent and chronic UTI for over 15 years. Together, Melissa, Kiran, and Harry walk through how recurrent UTI and chronic UTI are defined, and why the lack of NHS guidelines for chronic UTI leaves patients getting misdiagnosed with conditions like painful bladder syndrome (interstitial cystitis), overactive bladder, or the genitourinary syndrome of menopause. The conversation also covers the two trial arms, with extended full-dose antibiotics plus methenamine hippurate compared against the current NICE-recommended low-dose prophylaxis informed by the ULTA study. They explain why fresh urine microscopy is being used as the primary endpoint instead of standard MSU culture alone, the perineal swab approach to tracking antimicrobial resistance, who is eligible for the trial, and how to access screening at the five UK trial sites (Whittington, UCLH, Guy’s and St Thomas’, Manchester St Mary’s, and Newcastle). Recruitment closes August 2027, with first results expected in early 2028. Key Takeaways 1. ETAP is the first RCT built around a clinical definition of chronic UTI. It defines the condition as continuous daily urinary symptoms lasting more than three months, with acute flares in between. 2. The trial looks at the host response, not just the bacteria. Fresh urine microscopy checks for white blood cells as a sign of an immune response, giving same-day results instead of a two-to-three-day wait for culture. 3. The design reflects what patients actually need. Clinicians choose the antibiotic based on tolerability and history. D-mannose, cranberry, and vaginal oestrogen are allowed, flares are managed with rescue therapy, and travel is reimbursed up to £45. Links and Resources Mentioned * Learn more about EAT-UP Trial: https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbDlDS3gtWWFTdXRhRk5iUHJzYkJjY0FNMVRnQXxBQ3Jtc0tsNVBtaExkN0JiVEJ1aEhMMUZLUWRfVHhmNVA3ZnMwcFNnLUJuemNOeHNxdjFlZlB4LXdTMk5LdklXekZDMnZDb1BGbEducE9ZRzB2QkJVUmtlc29jWTFwbjF6aVk1d2pFTEw2eWpiZHgwcG1NWDhuNA&q=https%3A%2F%2Fwww.isrctn.com%2FISRCTN17592593&v=D-YV9GR6peAhttps://www.isrctn.com/ISRCTN17592593 [https://www.isrctn.com/ISRCTN17592593] * Get in touch with the research team: whh-tr.researchanddevelopment@nhs.net  [whh-tr.researchanddevelopment@nhs.net] * Watch our previous interview with Dr. Harry Horsley: https://www.youtube.com/watch?v=pq1K1zBt7Ho [https://www.youtube.com/watch?v=pq1K1zBt7Ho] * More on the science behind chronic urinary tract infection: https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbFJQb3NZUmp5cThNcWZuNVFsb3VuVHF5cVFrZ3xBQ3Jtc0tsNy1iVHZJWUVabmpKVEs2bm9yS2xsNVNuTERHWktJYk9NZWpkeU5rVnphSDl1cVZXelFxYkk1M3B5LW92Uk94ZW0zUG55LUxNZkhWVWRrdmlCQ0F0SDNXaE52SXpOZVF5MjlyTGpONHRDQ0ZfY3pwQQ&q=https%3A%2F%2Fliveutifree.com%2Fchronic-urinary-tract-infection&v=D-YV9GR6peAhttps://liveutifree.com/chronic-urinary-tract-infection/ [https://liveutifree.com/chronic-urinary-tract-infection/]

Chronic UTI Prevention, Bladder Tea, & D-Mannose | Julia Anditsch with Live UTI Free (LUF)

What if your bladder isn’t working against you, but trying to tell you something? In this episode of the Live UTI Free podcast, host Melissa Kramer sits down with Julia Anditsch, founder of Die Blase (German for “The Bladder”), an international bladder health platform based in Germany and Austria, and creator of Die Blase To Go, the first ready-to-drink bottled bladder tea. Together, Julia and Melissa get into the tools, tests, and daily habits that patients in their communities are actually using to manage recurrent and chronic UTI. They cover D-mannose; lactic acid bacteria probiotics for the gut and vagina; bladder teas made with nettle, goldenrod, birch leaf, ginger, and mint; Hiprex (methenamine hippurate); and the UK ULTA study; UTI vaccines like Uromune, Uro-Vaxom, and Strovac; the importance of testing for STIs and ureaplasma alongside UTI; and the emerging research connecting the urogenital microbiome to fertility and pregnancy. Whether you’re newly diagnosed or years into a chronic UTI journey, this conversation offers real patient experience, science, and a reminder that you’re not alone. What You’ll Learn * Why standard urine dipsticks and cultures can miss infections, and what tests like vaginal swabs, PCR, and STI panels may pick up. Plus, why looking at bladder, gut, and vaginal health together can offer a more complete picture. * What alternatives and add-ons to antibiotics are being explored in the community. This includes D-mannose, probiotics, bladder teas, Hiprex (methenamine hippurate), and vaccines like Uromune, Uro-Vaxom, and Strovac. Also covered: what’s known, what’s still being researched, and how access varies by country. * Which everyday factors often come up as possible UTI triggers, including heat, cold feet, dehydration, stress, and sex. Plus, simple daily habits some people find helpful alongside their treatment plan. Resources and Links * Learn more and access related articles: liveutifree.com [http://liveutifree.com/] * Subscribe to the LUF YouTube channel [https://www.youtube.com/@LiveUTIFree] for video format

Why UTI Tests Keep Failing You And What Science Is Doing About It | Prof. Jenny Roan with Live UTI Free

If you’ve ever been told your urine test came back negative but you know something is wrong, this episode is for you. Host Melissa Kramer speaks with Professor Jenny Roan, Head of the Centre for Urological Biology at University College London (UCL), to get into the science that most people living with recurrent or chronic UTI desperately want to understand. From why the dipstick test misses so many real infections, to what’s actually happening inside the bladder wall when antibiotics stop working, Professor Roan breaks it all down in plain language, without dismissal. Professor Roan also shares details of a novel treatment her team at UCL has developed, CapFuran, a microencapsulated nitrofurantoin designed to deliver the antibiotic directly into the bladder wall to target embedded bacteria and biofilms that standard antibiotics simply can’t reach. With a potential clinical trial horizon of 2026–2027, this is the research the chronic UTI community has been waiting for. 3 Key Takeaways 1. Your negative test result doesn’t necessarily mean there’s no infection. Dilution, the wrong type of bacteria, mixed growth being discarded… There are multiple scientific reasons a real UTI can be missed. The research highlighting these inadequacies has existed for decades. 2. Chronic UTI may involve bacteria that are literally hiding inside your bladder wall. These intracellular bacteria and biofilms are dormant and largely unreachable by standard short-course antibiotics, which is why a three-day course of nitrofurantoin often isn’t enough. 3. Research into new treatments is moving forward and the patient community is part of the push. From the uro-immune vaccine to a novel encapsulated antibiotic therapy targeting embedded infection, there are promising options in development. The more patients ask questions and advocate for themselves, the harder it becomes to ignore this area of health. Resources and Links * Learn more and access related articles: https://www.liveutifree.comliveutifree.com [http://liveutifree.com] * Subscribe to the LUF YouTube channel [https://www.youtube.com/@LiveUTIFree] for video format * Connect with Professor Jenny Roan via UCL [https://profiles.ucl.ac.uk/6235-jennifer-rohn] or LinkedIn [https://uk.linkedin.com/in/jennifer-rohn-9498661]

Why Chronic UTI Symptoms Can Worsen With Stress | Dr. Aparna Taylor with Live UTI Free

Can stress really trigger chronic UTI symptoms? In this episode of the Live UTI Free Podcast, host Melissa Kramer speaks with Dr. Aparna Taylor about the connection between stress, the nervous system, inflammation, gut health, and chronic UTI symptoms. Dr. Taylor explains why stress is not just about feeling “stressed out,” but about the body perceiving a threat to survival. She breaks down how being stuck in fight, flight, or freeze can affect immune function, sleep, digestion, and healing, and why that matters so much for people living with chronic bladder symptoms. The conversation also explores why symptoms can flare during stressful moments; whether stress reduction alone can resolve an infection; how movement, mindfulness, and calming routines may support healing; and why diet and gut health can be important pieces of the bigger picture. Throughout the episode, Dr. Taylor emphasizes an individualized, sustainable approach that looks beyond the bladder alone. If you’ve ever wondered why your symptoms seem to spike when life feels overwhelming, or why one-size-fits-all advice has not worked for you, this episode offers a grounded and compassionate perspective on chronic UTI recovery. 3 takeaways * Why chronic UTI symptoms may flare during stressful moments, and how pain, inflammation, poor sleep, and nervous system overload can all add up. * How gut health, food sensitivities, and inflammation may play a role in chronic illness, and why dietary changes often need to be individualized. * Why recovery is often about finding a sustainable, realistic, whole-person approach rather than chasing one perfect treatment or “silver bullet.” Want to learn more about urinary health? Visit LiveUTIFree.com [http://liveutifree.com/] for expert articles on the latest research, or check out our YouTube channel [https://www.youtube.com/@LiveUTIFree] for a video format.

Mold Toxicity & Chronic Bladder Symptoms | Dr. Pamela Cipriano with Live UTI Free (LUF)

Could hidden mold exposure or fungal overgrowth be aggravating your chronic UTI symptoms, even when standard urine cultures come back “negative”? In this episode of the Live UTI Free Podcast, host Melissa (CEO of Live UTI Free) speaks with Dr. Pamela Cipriano, a doctorally-prepared nurse practitioner in Connecticut who practices internal and functional medicine and works with patients experiencing chronic urinary tract infections, chronic bladder pain, mold toxicity, Candida overgrowth, and tick-borne illnesses. Dr. Cipriano explains why the terms mold and fungi are essentially interchangeable, how mold can affect the immune system and irritate the bladder, and why some people can live in the same environment yet one person gets very sick, and the other feels fine. You’ll also hear her approach to testing when symptoms persist, including why she uses MicroGenDX to look beyond a standard culture for what may be embedded in the bladder wall, plus how she thinks about biofilms as a “hiding place for bacteria, mold, fungus.” 3 things you’ll learn in this episode: * Why mold and fungi are often used interchangeably, and what “mold toxicity” / mycotoxin illness can look like, from sinus issues to “Candida outbreaks” to urinary symptoms. * How Dr. Cipriano approaches chronic UTI cases when symptoms persist: MicroGenDX DNA-based testing, plus what she looks for when she suspects bladder wall infection and fungal involvement. * What might make urinary symptoms flare during treatment, including inflammatory reactions, and why Dr. Cipriano puts so much weight on hydration and anti-inflammatory nutrition. Want to learn more about urinary health? Visit LiveUTIFree.com [http://liveutifree.com/] for expert articles on the latest research, or check out our YouTube channel [https://www.youtube.com/@LiveUTIFree] for a video format.