56 | Finally! New Hope for Joints, Cartilage, and Aging Bodies: Urolithin A
What if the real reason behind your joint pain and muscle fatigue isn’t just age or wear and tear, but your cells running out of energy?
In this compelling solo episode, Stacy Roberts dives deep into the groundbreaking science of urolithin A, a compound your body could make from healthy foods like pomegranates and walnuts if your gut microbiome is up to the task.
With warmth and hard-won insight, she breaks down how mitochondrial health impacts pain, recovery, and aging at a cellular level. Learn why some people don’t benefit enough from diet alone, how supplementation can jumpstart healing, and what the latest research actually shows for joint, muscle, and whole-body health.
If you’re doing everything right and still feel stuck, this is the crucial missing layer you need to hear about. Press play to shift your healing from the inside out!
TIMESTAMPED HIGHLIGHTS
* 01:10 — Are you chasing symptoms or seeking root causes?
* 03:10 — Why joint pain and fatigue may mean your cells lack energy
* 05:05 — Not everyone benefits from healthy foods—gut microbiome differences explained
* 08:15 — The power of mitophagy: how your body recycles damaged mitochondria
* 10:00 — Human trials: real improvements in muscle endurance and inflammation
* 12:05 — Can urolithin A actually slow cartilage degeneration?
* 13:43 — What to look for in supplements: Mitopure and evidence-backed choices
* 16:00 — Who will benefit most, especially women in menopause and the “doing everything right” group
* 18:39 — The crucial question: “Do my cells have the energy they need to heal?”
RESOURCES:
MITOPURE SUPPLEMENT - PURCHASE ON AMAZON [https://amzn.to/4tQdhfY]
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REFERENCES:
1. Selma MV, Beltrán D, García-Villalba R, Espín JC, Tomás-Barberán FA. Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. Food Funct. 2014;5(8):1779-1784. doi:10.1039/c4fo00092g https://pubmed.ncbi.nlm.nih.gov/24909569/ [https://pubmed.ncbi.nlm.nih.gov/24909569/]
2. Short KR, Bigelow ML, Kahl J, et al. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci U S A. 2005;102(15):5618-5623. doi:10.1073/pnas.0501559102 https://www.pnas.org/doi/10.1073/pnas.0501559102 [https://www.pnas.org/doi/10.1073/pnas.0501559102]
3. Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1(6):595-603. doi:10.1038/s42255-019-0073-4 https://www.nature.com/articles/s42255-019-0073-4 [https://www.nature.com/articles/s42255-019-0073-4]
4. Liu S, D'Amico D, Shankland E, et al. Effect of urolithin A supplementation on muscle endurance and mitochondrial health in older adults: a randomized clinical trial. JAMA Netw Open. 2022;5(1):e2144279. doi:10.1001/jamanetworkopen.2021.44279 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244 [https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244]
5. Singh A, D'Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5):100633. doi:10.1016/j.xcrm.2022.100633 https://www.sciencedirect.com/science/article/pii/S2666379122001049 [https://www.sciencedirect.com/science/article/pii/S2666379122001049]
6. D'Amico D, Olmer M, Fouassier AM, et al. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell. 2022;21(8):e13662. doi:10.1111/acel.13662 https://onlinelibrary.wiley.com/doi/10.1111/acel.13662 [https://onlinelibrary.wiley.com/doi/10.1111/acel.13662]
IMPORTANT LINKS
* Pain-Free Formula Podcast - https://podcasts.apple.com/us/podcast/the-pain-free-formula/id1802518411 [https://newyouhealthandwellness.com/painfreepodcast]
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* Free eBooks - https://newyouhealthandwellness.com/ebooks [https://newyouhealthandwellness.com/ebooks]
* Biomechanics: When Movement Matters [https://newyouhealthandwellness.com/ebooks]
* Heal Your Gut, Heal Your Pain - The Gut Joint Axis: A Missing Link to Joint and Muscle Health [https://newyouhealthandwellness.com/ebooks]
* Hormones: A Missing Piece in Pain Relief [https://newyouhealthandwellness.com/ebooks]
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* Stacey’s Book on Amazon [https://www.amazon.ca/Pain-Free-Formula-Solving-Injections/dp/0998183717] - https://www.amazon.ca/Pain-Free-Formula-Solving-Injections/dp/0998183717 [https://www.amazon.ca/Pain-Free-Formula-Solving-Injections/dp/0998183717]
* New You Health and Wellness Website - https://newyouhealthandwellness.com [https://newyouhealthandwellness.com]
ABOUT THE HOST
Stacey Roberts, PT, MBA, MSN, RN, is an Amazon bestselling author, physical therapist, registered nurse, and functional medicine specialist with 30+ years of experience. She founded and runs New You Health and Wellness in Wauwatosa, Wisconsin. Her program, detailed in her book, The Pain-Free Formula; Solving The Puzzle of Muscle and Joint Pain Without Surgery, Drugs or Injections, has helped thousands overcome chronic pain and reclaim their vitality.
The Pain-Free Formula Podcast is brought to you by Stacey Roberts. Production and editing by Podcast Your Brand [https://rebrand.ly/pybsr2026].
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