Dementia Matters

What if you could test your cognition from the comfort of your own home using a smartphone? Drs. David Berron and Lindsay Clark have spent years researching cognitive neuroscience, culminating in a 2024 published study investigating the effectiveness of a smartphone app as a tool for detecting cognitive impairment outside of a clinic or research setting. Drs. Berron and Clark join Dementia Matters to discuss how the app and tests were developed, the benefits and drawbacks of this approach  and the implications of remote testing in the healthcare field. Guests: David Berron, PhD, Clinical Cognitive Neuroscience research group leader, German Center for Neurodegenerative Diseases (DZNE), and Lindsay Clark, PhD, licensed neuropsychologist, clinical core co-lead, Wisconsin Alzheimer’s Disease Research Center (ADRC), assistant professor, Division of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health Show Notes Read Drs. Berron and Clark’s study, “A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices [https://www.nature.com/articles/s41746-024-00999-9],” online through the journal npj Digital Medicine. Learn more about Dr. Berron and his research on his website. [https://davidberron.com/] Learn more about Dr. Clark on her profile [https://www.adrc.wisc.edu/lindsay-clark-phd] on the Wisconsin ADRC’s website. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production.

If you get the recommended eight hours of sleep per night, you spend a third of your life asleep. Why dedicate so much time to sleeping, and how can one get the most out of those eight hours? In this episode, Dr. Allison Reiss joins us for an insightful conversation about how sleep helps the brain, what the brain does while we are asleep, tips for improving one’s sleep hygiene and much more.  Guest: Allison Reiss, MD, internal medicine physician, head, Inflammation Laboratory, New York University (NYU) Langone Hospital-Long Island, associate professor of medicine, NYU Grossman Long Island School of Medicine, member, Medical, Scientific & Memory Screening Advisory Board, Alzheimer’s Foundation of America Show Notes For more information about sleep, listen to our episode with Dr. Steven Barczi, “The Importance of Sleep for a Healthy Life [https://www.adrc.wisc.edu/dementia-matters/importance-sleep-healthy-life],” mentioned by Dr. Chin at 1:40. Learn more about Dr. Reiss and her publications from her profile on the NYU Grossman Long Island School of Medicine [https://medli.nyu.edu/faculty/allison-b-reiss]website. Learn more about the Alzheimer’s Foundation of America’s Medical, Scientific & Memory Screening Advisory Board, which includes Drs. Chin and Reiss, by visiting their website [https://alzfdn.org/about-us/medical-scientific-advisory-boards/]. Learn more about the Wisconsin Registry for Alzheimer’s Prevention (WRAP) on their website [https://wrap.wisc.edu/]. View 9 sleep tips from the Wisconsin Alzheimer’s Disease Research Center (ADRC) Watch a recording of “Sleeping Your Way to Better Brain Health” presented by Dr. Steven Barczi. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production.

Dr. Reisa Sperling returns for another episode of Dementia Matters. After covering her research focused on preclinical Alzheimer’s disease in part one, Dr. Sperling dives deeper into the different factors that can impact cognitive decline and early-stage Alzheimer’s disease and how clinical trials are shaping the field’s understanding of detecting, treating and preventing the disease. Guest: Reisa Sperling, MD, director, Center for Alzheimer Research and Treatment (CART), co-principal investigator, Harvard Aging Brain Study, principal investigator, Alzheimer’s Clinical Trials Consortium (ACTC), co-leader, A4 Study, co-leader, AHEAD 3-45 Study, professor of neurology, Harvard Medical School   Show Notes Listen to our first episode with Dr. Sperling, “Defining and Addressing Preclinical Alzheimer’s Disease,” on Spotify [https://open.spotify.com/episode/4UxfU7m3f5SZaCFHmYKzRJ?si=8PcHpMOWTgeS89i0Zp7owQ], Apple Podcasts [https://urldefense.com/v3/__https://podcasts.apple.com/us/podcast/defining-and-addressing-preclinical-alzheimers-disease/id1292353638?i=1000669005962__;!!Mak6IKo!NB-iooaC8tWDTWWDKQTPDgLujCM6LDuH9LxRrtHmGGrqgJ3jb4EDZFTEzTZ3a8SijVpkweGl03Yyv0rbTi_mEWhB4os$] and on our website. [https://www.adrc.wisc.edu/dementia-matters/defining-and-addressing-preclinical-alzheimers-disease] Read more about the Harvard Aging Brains Study on their website. [https://habs.mgh.harvard.edu/] Read more about the AHEAD Study on their website. [https://www.aheadstudy.org/] Watch “Voices from the AHEAD Alzheimer’s Disease Trial,” featuring Dr. Cynthia Carlsson and a research participant, on YouTube.  Learn more about the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s disease (A4) study here. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049292/] Learn more about Dr. Sperling in her profile on the Massachusetts General Hospital website [https://www.massgeneral.org/doctors/17776/reisa-sperling].   Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production.

What if there was a way to detect Alzheimer’s disease before clinical signs and symptoms even appeared? Dr. Reisa Sperling joins Dementia Matters for a two-part series covering her research on detecting and treating Alzheimer’s disease at the earliest possible stage, known as preclinical Alzheimer’s. In this episode, Dr. Sperling goes in-depth on amyloid and tau proteins and the implications on early detection and treatment strategies for Alzheimer’s disease. Guest: Reisa Sperling, MD, director, Center for Alzheimer Research and Treatment (CART), co-principal investigator, Harvard Aging Brain Study, principal investigator, Alzheimer’s Clinical Trials Consortium (ACTC), co-leader, A4 Study, co-leader, AHEAD 3-45 Study, professor of neurology, Harvard Medical School Show Notes Read more about the Harvard Aging Brains Study on their website. [https://habs.mgh.harvard.edu/] Read more about the AHEAD Study on their website. [https://www.aheadstudy.org/] Watch “Voices from the AHEAD Alzheimer’s Disease Trial [https://youtu.be/hYZBbEC3rWQ?si=xGg25zPCWXTujhpI],” featuring Dr. Cynthia Carlsson and a research participant, on YouTube.  Learn more about the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s disease (A4) study here. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049292/] Learn more about Dr. Sperling in her profile on the Massachusetts General Hospital website [https://www.massgeneral.org/doctors/17776/reisa-sperling]. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production.

An expanding field of research is looking at how the gut affects different parts of people’s health, but how does it affect brain health? Drs. Barb Bendlin and Tyler Ulland join the podcast to talk about their 2023 study, which suggests a link between gut health, aging and changes related to Alzheimer’s disease. They discuss their findings on how gut inflammation could impact brain health, as well as explain what it means to have good gut health and how food, medications, where one lives and other factors can impact the gut microbiome. Guests: Barbara Bendlin, PhD, professor, Division of Geriatrics and Gerontology, deputy director, University of Wisconsin (UW) Center for Health Disparities Research, and Tyler Ulland, PhD, associate professor of pathology and laboratory medicine, UW School of Medicine and Public Health, leader, Ulland Lab Show Notes Learn more about the 2024 Fall Community Conversation: The Impact of Social Connections on Brain Health and register to attend in person [https://go.wisc.edu/u873wb] on our website. Read Dr. Bendlin and Dr. Ulland’s study, “Gut inflammation associated with age and Alzheimer’s disease pathology: a human cohort study [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646035/],” on the National Library of Medicine website. Learn more about Dr. Bendlin and Dr. Uland’s study in the article, “Gut inflammation linked to aging and Alzheimer’s disease [https://med.wisc.edu/news/gut-inflammation-aging-alzheimers-link/],” on the UW School of Medicine and Public Health website. Learn more about Dr. Ulland from his profile on the Ulland lab webpage [https://ulland.pathology.wisc.edu/staff/ulland-tyler/]. Learn more about Dr. Bendlin from her profile on the UW Center for Health Disparities Research website [https://chdr.wisc.edu/staff/bendlin-barbara/]. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production.