Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

Living organisms seem exquisitely organized and complex, with features clearly adapted to serving certain functions needed to survive and procreate. Natural selection provides a compelling explanation for why that is so. But is there a bigger picture, a more general framework that explains the origin and evolution of functions and complexity in a world governed by uncaring laws of physics? I talk with planetary scientist and astrobiologist Michael Wong about how we can define what "functions" are and the role they play in the evolution of the universe. Support Mindscape on Patreon [https://www.patreon.com/seanmcarroll]. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/16/299-michael-wong-on-information-function-and-the-origin-of-life/ [https://www.preposterousuniverse.com/podcast/2024/12/16/299-michael-wong-on-information-function-and-the-origin-of-life/] Michael Wong received his Ph.D. in planetary science from Caltech. He is currently a Sagan Postdoctoral Fellow at the Carnegie Institution for Scienceʼs Earth & Planets Laboratory. He is in the process of co-authoring two books: A Missing Law: Evolution, Information, and the Inevitability of Cosmic Complexity with Robert M. Hazen, and a revised edition of Astrobiology: A Multidisciplinary Approach with Jonathan Lunine. * Web site [https://miquai.myportfolio.com/] * Carnegie web page [https://carnegiescience.edu/bio/dr-michael-l-wong] * Strange New Worlds podcast [https://soundcloud.com/strange-new-worlds] * Wong et al. (2023), "On the Roles of Function and Selection in Evolving Systems [https://www.pnas.org/doi/10.1073/pnas.2310223120]." * Wong and Prabhu (2023), "Cells as the First Data Scientists [https://royalsocietypublishing.org/doi/10.1098/rsif.2022.0810]." See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome [https://en.wikipedia.org/wiki/Connectome]: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies. Support Mindscape on Patreon [https://www.patreon.com/seanmcarroll]. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/ [https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/] Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow [https://en.wikipedia.org/wiki/Brainbow] system for imaging neurons. He is a member of the National Academy of Sciences. * Web page [https://lichtmanlab.fas.harvard.edu/people/jeff-lichtman] * Lab web site [https://lichtmanlab.fas.harvard.edu/] * Google Scholar publications [https://scholar.google.com/citations?user=nwbMyO0AAAAJ&hl=en] * Wikipedia [https://en.wikipedia.org/wiki/Jeff_W._Lichtman] See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Welcome to the December 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters [https://www.patreon.com/seanmcarroll] (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2024/12/02/ama-december-2024/ [https://www.preposterousuniverse.com/podcast/2024/12/02/ama-december-2024/] Support Mindscape on Patreon [https://www.patreon.com/seanmcarroll]. See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Not too long ago, Brad Pitt and Eric Bana starred in a (loose) adaptation [https://en.wikipedia.org/wiki/Troy_(film)] of Homer's epic poem The Iliad; next month, Ralph Fiennes and Juliette Binoche will headline a film [https://en.wikipedia.org/wiki/The_Return_(2024_film)] based on The Odyssey. Given that the originals were written (or at least written down) in the 8th century BCE, that is some impressive staying power. But they were also written in a very different time than ours, with different cultural context and narrative expectations. We talk about the issues of translation in general, and these Greek classics in particular, with Emily Wilson, whose recent translations of The Iliad [https://bookshop.org/p/books/the-iliad-homer/17147944?ean=9781324001805] and The Odyssey [https://www.amazon.com/Odyssey-Homer/dp/0393089053] have garnered worldwide acclaim. Support Mindscape on Patreon [https://www.patreon.com/seanmcarroll]. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/11/25/297-emily-wilson-on-homer-poetry-and-translation/ [https://www.preposterousuniverse.com/podcast/2024/11/25/297-emily-wilson-on-homer-poetry-and-translation/] Emily Wilson received her Ph.D. in classical and comparative literature from Yale. She is currently Professor of Classical Studies at the University of Pennsylvania. Among her awards are the Charles Berheimer Prize from the American Comparative Literature Association, a Rome Prize fellowship from the American Academy in Rome, and Guggenheim and MacArthur fellowships. * Web site [https://www.emilyrcwilson.com/] * UPenn web page [https://www.classics.upenn.edu/people/emily-wilson] * Wikipedia [https://en.wikipedia.org/wiki/Emily_Wilson_(classicist)] * Amazon.com author page [https://www.amazon.com/stores/Emily-R.-Wilson/author/B001H6S1IE] * YouTube [https://www.youtube.com/@emilyrcwilson1796] * Substack [https://substack.com/@emilyrcwilson] * BlueSky [https://bsky.app/profile/emilyrcwilson.bsky.social] See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Biological evolution via natural selection is a simple idea that becomes enormously complicated in its realization. Populations of organisms are driven toward increased "fitness," a measure of how successfully we reproduce our genetic information. But fitness is a subtle concept, changing with time and environment and interactions with other organisms around us. We talk with biologist Brandon Ogbunu about the best mathematical and conceptual tools for thinking about the messy complexities of evolution, and how modern technology is changing our way of thinking about it. Support Mindscape on Patreon [https://www.patreon.com/seanmcarroll]. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/11/18/296-brandon-ogbunu-on-fitness-seascapes-and-the-course-of-evolution/ [https://www.preposterousuniverse.com/podcast/2024/11/18/296-brandon-ogbunu-on-fitness-seascapes-and-the-course-of-evolution/] Brandon Ogbunu received his Ph.D. in Genetics and Microbiology from Yale University. He is currently Assistant Professor of Ecology and Evolutionary Biology at Yale, and External Faculty at the Santa Fe Institute. He has been awarded a Fullbright Fellowship and was the Martin Luther King Jr. Visiting Professor at MIT. He has contributed to a number of publications, including Wired [https://www.wired.com/author/c-brandon-ogbunu/], Undark [https://undark.org/undark-author/c-brandon-ogbunu/], and Quanta [https://www.quantamagazine.org/authors/c-brandon-ogbunu/]. * Lab web site [https://ogbunulab.yale.edu/] * Yale web page [https://eeb.yale.edu/people/faculty/c-brandon-ogbunu] * Google Scholar publications [https://scholar.google.com/citations?user=rHUzZs0AAAAJ&hl=en] * Wikipedia [https://en.wikipedia.org/wiki/Brandon_Ogbunu] * Public talk: What is Lyfe? Towards a Biology of Context & Complexity [https://www.youtube.com/watch?v=8rRNbiYg7fs&ab_channel=SantaFeInstitute] See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].