The SMART Healthcare Podcast

Understanding Translational Science w. Chris Austin (Pt. 3) - The Future of Translational Science

In the third and final part of this series on translation science, Matthew interviews Dr. Chris Austin, SVP of Research Technologies at GSK, about what the future holds for translational science. Chris discusses the innovations that will help us figure out new and more rapid ways to develop therapeutics. As part of this Chris explains how data, machine learning, and artificial intelligence will play a key role in these advancements. Additionally, Chris discusses the importance and challenges of generating data that can serve multiple purposes across all stages of biomedical translation; Chris highlights the important role that collaboration has in this process. Chris and Matthew also discuss the EHR and the roll that it will play in the advancement of translational science. Chris also offers insight into the challenges behind using EHRs for translational science. Finally, Chris gives insight into the kinds of skills a person early on in their career needs to focus on building to set themselves up for a career doing translational science. Throughout all three parts of this interview, Chris references a few papers. Links to each can be found here: "Translating Translation": ⁠https://ictr.johnshopkins.edu/wp-content/uploads/Translating-Translation-Austin-2018.pdf⁠ "Opportunities and challenges in translational science": ⁠https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504824/⁠ "The Fundamental Characteristics of a Translational Scientist": ⁠https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088880/ ** Please note that this episode was recorded prior to Chris's move to GSK.

Understanding Translational Science w. Chris Austin (Pt. 2) - National Center for Advancing Translational Sciences

In the second episode of this three part series on translational science, Matthew interviews Dr. Chris Austin, CEO of Vesalius Therapeutics about the National Center for Advancing Translational Sciences (NCATS) and what lessons can be learned from its success.  Chris discusses the origins of NCATS, stemming from the ground-breaking insights brought by the completion of the Human Genome Project in 2003. Chris explains how NCATS sought to break down the process of biomedical translation into comprehendible steps that could each be assessed for efficacy and efficiency. Finally, Chris gives examples of some of the "rate limiting steps" in translation that NCATS identified and how the organization tackled these issues. Throughout all three parts of this interview, Chris references a few papers. Links to each can be found here: "Translating Translation": ⁠https://ictr.johnshopkins.edu/wp-content/uploads/Translating-Translation-Austin-2018.pdf⁠ [https://ictr.johnshopkins.edu/wp-content/uploads/Translating-Translation-Austin-2018.pdf] "Opportunities and challenges in translational science": ⁠https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504824/⁠ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504824/] "The Fundamental Characteristics of a Translational Scientist": ⁠https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088880/ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088880/]

Understanding Translational Science w. Chris Austin (Pt. 1) - What is Translational Science?

In the first episode of this three part series on translational science, Matthew interviews Dr. Chris Austin, CEO of Vesalius Therapeutics about what the discipline of translational science is. Chris gives his definition of the process of biomedical translation, as well as what translational science is and how it relates to this overall process. Chris highlights how translational science seeks to understand the reasons behind why therapeutics fail and how these factors can be mitigated, with the ultimate goal of accelerating the development of novel therapeutics. Throughout all three parts of this interview, Chris references a few papers. Links to each can be found here: "Translating Translation": https://ictr.johnshopkins.edu/wp-content/uploads/Translating-Translation-Austin-2018.pdf [https://ictr.johnshopkins.edu/wp-content/uploads/Translating-Translation-Austin-2018.pdf] "Opportunities and challenges in translational science": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504824/ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504824/] "The Fundamental Characteristics of a Translational Scientist": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088880/ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088880/]

Introduction to Digital Health (Pt. 3) - How You Can Get Involved

In this episode of the SMART Healthcare Podcast, Matthew conducts a three part interview of Dr. Brian Anderson, Chief Digital Health Physician at MITRE. In the final part of the series, Dr. Anderson sheds light on the skills that someone interested In a career in digital health should build.

Introduction to Digital Health (Pt. 2) - What Challenges Does Digital Health Face?

In this episode of the SMART Healthcare Podcast, Matthew conducts a three part interview of Dr. Brian Anderson, Chief Digital Health Physician at MITRE. In part two of this interview, Dr. Anderson describes the challenges that digital health is facing, particularly with regards to creating safe, trustworthy, and effective models. Dr. Anderson explains how the Coalition for Health AI (CHAI) brings over 730 different organizations together to facilitate the creation of responsible, trustworthy, and transparent health AI.