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Like fingerprints, no two cancers are exactly the same. And yet cancer care – especially for those in the most advanced stages, and with the most complex cases – is administered according to standard, linear protocols. Clinical trials, too, rely on examining one course of treatment against another without modifying the trial based on actual patient outcomes. Cancers are dynamic. They build resistance. They adapt. So why don’t we adapt cancer treatment for each individual, each tumour? In this episode, Juliet sits down with Dr. Jack Kreindler to talk about adaptive oncology, the challenges of putting it into practice, and the opportunities for startups to address the massive unmet need in cancer treatment. Dr. Jack is a leading expert in health optimisation, co-founder of the Centre for Health and Human Performance, a serial- entrepreneur, and our very own Venture Partner here at Mosaic.

Mosaic Ventures In Conversation With Y Combinator President Sam Altman by Mosaic Ventures

In the latest episode of the Mosaic Podcast we are joined by Pascal Gauthier, who over the last 15 years has been immersed in some of the fastest growing digital media and adverting companies out of Europe. Starting his career in price comparison service Kelkoo (Link) (Aqd Yahoo), he joined Criteo (link) in 2008 as a fledging startup where he remained as COO until its IPO on the NASDAQ where it is now valued at 3bn. last year joined us as a Venture Partner based in Paris. In the podcast we discuss building and scaling Criteo, competing with google and expanding into the US. In addition, we examine the rapidly growing Paris technology ecosystem.

We wrote last April about the opportunity for habito to bring mortgages into the 21st century. Mortgages are an enormous category, over £200 billion in the UK alone. Yet for a commodity-like product - who cares which lender your money comes from - it is exceedingly complex for a consumer to find the right mortgage, struggle through the jargon, and the mountain of paperwork, then stay on the best deal forever. habito changed all of this in less than 12 months. Their AI-powered chatbot provides the right advice to homebuyers in minutes, with access to over 60 lenders and 10,000 mortgage products, and takes care of getting them the mortgage they need. Having worked closely with Daniel and the habito team for 18 months, we know that while this consumer feat may appear simple, the product development effort to achieve it has been enormous and has involved many iterations. And we know this is just the beginning for them as they seek to become the future of mortgages. Daniel’s vision is to stand side-by-side with customers as they navigate one of their most critical life decisions, and to completely reinvent the mortgage experience. Using software to automate this process end-to-end is the goal for the next few years, and habito will soon be in a position to create new types of mortgage products, such as real-time completion or personalised yield curves and capital repayments. We love entrepreneurs who are reinventing so-called boring categories like mortgages and we see many other opportunities within financial services. So, if you’re working on a big idea in the space, please get in touch.

In this podcast, Mosaic partners Simon Levene and Mike Chalfen explore with Sam Altman his interest in “hard tech” sectors including Energy and Synthetic Life. Sam also discusses YC’s strategy and future including the new $700 continuity fund as well as the launch of YC research, a nonprofit research lab (including the famed initiative around universal basic income). In the second half of the podcast, Mike goes deep on AI, asking Sam: How and when will AI become a dominant force in our lives? Will there be a single AI, a benevolent dictator or a world of multiple AIs with no one dominant AI? Who will regulate this AI? How can governance be globally effective? Will AI create a world of infinite wealth? And in this world how will humans achieve status, fulfillment and happiness?