The Human Upgrade: Biohacking for Longevity & Performance

What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR [https://www.youtube.com/@DaveAspreyBPR]  Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men’s health through functional medicine and advanced supplementation.  In this high-energy, high-clarity conversation, the trio explore what’s working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You’ll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health.   You’ll Learn:  • Who should use estradiol—and how it can protect brain performance in men  • The real role of testosterone and estradiol synergy in male health and longevity  • How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health  • Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care  • The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15  • What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks  • Why libido and metabolic health are deeply connected  • The dangers of unvetted peptide sources—and what to look for in quality and bioavailability  This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living.  Keyword Index:  estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.  Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.   Thank you to our sponsors!   * Puori | Head to http://puori.com/dave [http://puori.com/dave] for 20% off, including subscriptions.   * Leela Quantum Tech | Head to https://leelaq.com/DAVE [https://leelaq.com/DAVE] for 10% off.   * ARMRA | Go to https://tryarmra.com/ [https://tryarmra.com/] and use the code DAVE to get 15% off your first order.   Resources:   • BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE# [https://biolongevitylabs.com/?ref=DAVE#]  • Dave Asprey’s Website: https://daveasprey.com [https://daveasprey.com/]  • Danger Coffee: https://dangercoffee.com/DAVE15 [https://dangercoffee.com/DAVE15]  • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]  • Upgrade Collective: https://www.ourupgradecollective.com [https://www.ourupgradecollective.com/]  • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]  • 40 Years of Zen: https://40yearsofzen.com [https://40yearsofzen.com/]  Timestamps:  00:00 – Trailer  01:00 – Introduction & Early Days of Biohacking  02:03 – Peptides 101: Foundations and Frameworks  03:06 – Peptides for Healing, Cognition, and Longevity  07:56 – Bioregulators and Russian Innovations  11:07 – Side Effects and Safety of Peptides  22:27 – Oral Peptides and Product Innovations  27:41 – Body Composition, Hormones, and Fat Loss  32:02 – Testosterone, Estrogen, and Male Health Protocols  45:03 – Peptides for Performance, Fat Loss, and Longevity  1:26:32 – Loose Skin, Surgery, and Body Transformation  1:38:00 – Closing Thoughts & Product Recommendations  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about? This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR [https://www.youtube.com/@DaveAspreyBPR]  Host Dave Asprey sits down with Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health. Known for his fearless, data-driven experimentation, Lucas specializes in nootropics, dopamine modulation, mitochondria, and functional medicine. He’s spent over a decade testing underground compounds, natural molecules, and hormone-based strategies to achieve elite-level brain and body performance.  Together, they explore Russian-developed enhancers like Bromantane and ITPP, and reveal how these rare compounds impact dopamine regulation, neuroplasticity, and mental drive. You’ll learn how to upregulate tyrosine hydroxylase (your brain’s dopamine switch), build targeted stacks for motivation and confidence, and avoid the common supplements that quietly kill your ambition.  They also dive into the connection between dopamine and testosterone, explaining how to rewire hormonal feedback loops to reclaim masculinity, energy, and purpose. From libido hacks and prolactin suppression to stacking dopamine with GABA and acetylcholine, this episode gives you a complete system for motivation mastery.  Other key topics include the dangers of chronic ashwagandha use, sleep optimization for dopamine recovery, the truth about adaptogens and cold therapy, ketosis, fasting, DHT science, ciproheptadine microdosing, and why mitochondrial support is essential for long-term performance and metabolism.  You’ll Learn:  • The #1 Russian compound for explosive dopamine and drive  • Why most “calming” supplements destroy your ambition  • How dopamine and DHT shape masculinity and performance  • Advanced biohacks for sleep, motivation, libido, and mood  • The truth about serotonin dominance and how to escape it  • Which functional medicine tools enhance brain energy and metabolism  • How to build your own dopamine protocol using proven nootropics  • Why mitochondrial health is the hidden key to motivation and mood  This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.  Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.   Thank you to our sponsors!   * OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY [https://oneskin.co/ASPREY] with code ASPREY.   * Timeline | Head to https://www.timeline.com/dave [https://www.timeline.com/dave] to get 10% off your first order.   * LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE [https://drinklmnt.com/DAVE].   Resources:   • Lucas’s Website: https://www.boostyourbiology.com/ [https://www.boostyourbiology.com/]  • Lucas’s YouTube: https://www.youtube.com/c/boostyourbiology [https://www.youtube.com/c/boostyourbiology]  • Dave Asprey’s Website: https://daveasprey.com [https://daveasprey.com/]  • Danger Coffee: https://dangercoffee.com/DAVE15 [https://dangercoffee.com/DAVE15]  • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]  • Upgrade Collective: https://www.ourupgradecollective.com [https://www.ourupgradecollective.com/]  • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]  • 40 Years of Zen: https://40yearsofzen.com [https://40yearsofzen.com/]  Tags:   dopamine boosters, russian nootropics, bromantane benefits, biohacking dopamine, boost motivation naturally, dopamine stack, lucas aoun podcast, dave asprey dopamine, nootropics for energy, secret russian compounds, brain optimization, biohacking supplements, increase dopamine levels, functional medicine hacks, hormone optimization, dopamine and testosterone, neuroplasticity hacks, superhuman energy, underground nootropics, dopamine protocols  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Getting 50 grams of protein per meal may be the single most underrated biohacking protein strategy for muscle growth, metabolism, and longevity. In this episode, you’ll discover why animal protein vs vegan is not a fair match biologically, how hitting the leucine threshold activates mTOR for longevity, and why muscle is the most overlooked organ of aging. This is must-listen content for anyone optimizing human performance, hacking metabolism, or reversing muscle loss with food.  Host Dave Asprey is joined by Dr. Gabrielle Lyon, a pioneer in Muscle-Centric Medicine®, functional medicine expert, and top authority on clinical nutrition for longevity. Trained by protein researcher Dr. Donald Layman, she brings decades of expertise on how to use high-protein diets, amino acid science, and functional medicine to radically improve healthspan and brain optimization. Dr. Lyon works with everyone from special operators to aging patients, making her one of the most trusted voices in anti-aging diet strategies.  Watch this channel on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR [https://www.youtube.com/@DaveAspreyBPR]  You’ll learn:  • Why 50g of protein per meal matters more than total daily intake  • How mTOR and longevity are misunderstood in mainstream nutrition  • Why protein vs plant protein debates ignore hard biological data  • How leucine thresholds determine muscle activation  • Why fasting and protein cycling beats low-protein veganism  • How ketosis and protein intake impact metabolic health  • Why many on a vegan diet experience sleep issues, hormone crashes, and reduced resilience  • How functional medicine podcasts like this one reveal the truth about aging and muscle loss  • What happens clinically when patients switch to a high-protein diet  • How to use supplements, nootropics, and protein hacks to enhance neuroplasticity, mitochondrial energy, and total body performance  If you’ve ever asked “what’s the best protein for muscle growth?” or “how does protein affect metabolism in aging?”, this episode gives you evidence-based answers from the front lines of clinical nutrition.  This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you’re tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won’t hear anywhere else.   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.   Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.   Thank you to our sponsors!   * 40 Years of Zen | Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com [https://40yearsofzen.com/]  * fatty15 | Go to https://fatty15.com/dave [https://fatty15.com/dave] and save an extra $15 when you subscribe with code DAVE.   * Lumiram | Go to http://healthlighting.com/dave [http://healthlighting.com/dave] to save 10% on your order.   Resources:    • Gabrielle’s Website: https://drgabriellelyon.com/ [https://drgabriellelyon.com/]  • Gabrielle’s IG: https://www.instagram.com/drgabriellelyon/ [https://www.instagram.com/drgabriellelyon/]  • Dave Asprey’s Website: https://daveasprey.com [https://daveasprey.com/]  • Danger Coffee: https://dangercoffee.com/DAVE15 [https://dangercoffee.com/DAVE15]  • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]  • Upgrade Collective: https://www.ourupgradecollective.com [https://www.ourupgradecollective.com/]  • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]  • 40 Years of Zen: https://40yearsofzen.com [https://40yearsofzen.com/]    Timestamps:  • 0:00 Trailer  • 0:51 Protein Controversy   • 2:38 Leucine  • 6:00 mTOR, Methionine, and Protein Synthesis  • 9:00 Vegan vs. Carnivore  • 16:00 Optimizing Protein Intake & Aging  • 22:00 Carbohydrates, Hormones, and Female Health  • 28:00 Environmental Impact & Food Sourcing  • 34:00 Debunking Plant-Based Documentaries  • 40:00 Key Takeaways & Closing  Keywords: protein vs plant protein, 50 grams of protein, biohacking protein, mTOR and longevity, animal protein vs vegan, leucine threshold, Gabrielle Lyon, muscle-centric medicine, best protein for muscle growth, anti-aging diet, muscle as organ of longevity, fasting and protein, ketosis and protein, vegan diet risks, optimizing metabolism, high-protein diet, functional medicine podcast, Dave Asprey protein, aging and muscle loss, clinical nutrition for longevity  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

This episode reveals how military-grade sound frequencies can rapidly shift your mental state, enhance neuroplasticity, and accelerate brain optimization. You’ll learn how to hack your nervous system using real-time biometric data, how frequency compositions are changing functional medicine, and why sound is emerging as one of the most powerful tools for human performance and longevity.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR [https://www.youtube.com/@DaveAspreyBPR]  Host Dave Asprey is joined by Rev. Michael Beckwith, founder of the internationally renowned Agape International Spiritual Center and one of the most respected voices in spiritual transformation and human potential. With over four decades of teaching, Michael has impacted millions through his work in consciousness, meditation, and high-performance inner development. Joining him is Henry Penix, founder of SOAAK Technologies, a cutting-edge frequency healing platform trusted by clinicians, elite performers, and even the US Air Force. Together, they explore how sound can rewire brainwaves, reduce anxiety, support sleep optimization, and create measurable changes in metabolism, mood, and mindset.   You’ll learn:  • How the Air Force is using frequency tech to support mental recovery and cognitive performance  • What makes SOAAK’s custom sound compositions biologically effective  • How sound impacts mitochondria, mood, and brainwave coherence  • The link between sound healing, neuroplasticity, and high-performance states  • Why hydration, supplements, and biohacking stacks boost sound-based protocols  • The surprising connection between prayer, frequency, and emotional regulation  • How to integrate sound biohacks with fasting, ketosis, sleep tools, and nootropics  • Why this tech pairs with cold therapy, Danger Coffee, and smarter not harder principles  This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you’re tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won’t hear anywhere else.   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.  Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.   Thank you to our sponsors!   * Leela Quantum Tech | Head to https://leelaq.com/DAVE [https://leelaq.com/DAVE] for 10% off.   * Active Skin Repair | Visit http://activeskinrepair.com/ [http://activeskinrepair.com/] to learn more and use code DAVE to get 20% off your order.   * ARMRA | Go to https://tryarmra.com/ [https://tryarmra.com/] and use the code DAVE to get 15% off your first order   Resources:   • SOAAK Website: https://www.soaak.com/dave [https://www.soaak.com/dave]  • Dave Asprey’s Website: https://daveasprey.com [https://daveasprey.com/]  • Danger Coffee: https://dangercoffee.com/DAVE15 [https://dangercoffee.com/DAVE15]  • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]  • Upgrade Collective: https://www.ourupgradecollective.com [https://www.ourupgradecollective.com/]  • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]  • 40 Years of Zen: https://40yearsofzen.com [https://40yearsofzen.com/]  Timestamps:  • 0:00 — Trailer  • 1:00 — Intro  • 2:42 — Humor & Frequency  • 5:20 — Soak App Origins  • 8:15 — Biometrics & Sound Delivery  • 10:40 — Inner Alignment & Brain Mapping  • 13:46 — Beckwith’s Results  • 19:44 — Sound & Biohacking  • 23:32 — Mood & Sleep Shifts  • 24:53 — Supplements & Water Synergy  • 26:25 — Emotional Congruence  • 29:49 — Frequency & Sexuality  • 32:43 — Military & Medicine  • 35:32 — Light, Sound & Quantum Effects  • 40:34 — Analog vs. Digital Sound  • 48:45 — Spiritual Experiences  • 53:14 — Conclusion & CTA  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

You’ve been lied to about how long it takes to change a habit. This episode reveals a powerful, science-backed method to rewire your brain in just 63 seconds—without relying on willpower. You’ll discover how to use the 63-second window to interrupt destructive thought loops and how true habit change requires 63-day habit formation, not the popularized 21-day myth.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR [https://www.youtube.com/@DaveAspreyBPR]  Host Dave Asprey sits down with Dr. Caroline Leaf, a cognitive neuroscientist and best-selling author known for her groundbreaking work on the mind-brain connection. With over four decades of experience, Dr. Leaf has helped millions better understand the differences between the mind vs brain, how to harness intuition and neurobiology, and how to apply science-based tools for healing trauma with neuroscience. Her newest work, Help in a Hurry, builds on her bestselling book Cleaning Up Your Mental Mess, offering real-time tools to regain mental control during moments of emotional chaos.   You’ll learn:  • Why the 21-day habit myth persists and what the neuroscience actually shows  • How to use the 63-second window to stop toxic thoughts from wiring into your brain  • What happens during the 63-day habit formation cycle and how to stay on track  • The difference between the subconscious vs unconscious mind  • How to rewire your brain for better emotional regulation and decision-making  • The power of forgiveness and how it relates to quantum entanglement  • Caroline Leaf’s mental mess strategies to overcome triggers in real time  • Why the free will neuroscience debate matters for your mental sovereignty  • How to interpret intuitive “blips” through a neuroscience lens  • Tools for using neuroplasticity to heal trauma, manage emotions, and boost clarity  This episode is a must-listen for anyone interested in brain optimization, biohacking, human performance, mental resilience, and smarter-not-harder strategies for personal growth. Whether you’re focused on fasting, cold therapy, nootropics, sleep optimization, or upgrading your mitochondria, these mental frameworks will amplify your results.   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.   Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.  Thank you to our sponsors!   * Zbiotics | Go to https://zbiotics.com/DAVE [https://zbiotics.com/DAVE] for 15% off your first order  * IGNITON | Save 10% at https://endlss.io/sl/igniton/daveasprey [https://endlss.io/sl/igniton/daveasprey]  Resources:   • Order Caroline’s New Book ‘Help in a Hurry’ - https://a.co/d/6O9RaJB [https://a.co/d/6O9RaJB]  • Caroline's Website: https://drleaf.com/ [https://drleaf.com/]  • Dave Asprey’s Website: https://daveasprey.com [https://daveasprey.com/]  • Danger Coffee: https://dangercoffee.com/DAVE15 [https://dangercoffee.com/DAVE15]  • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]  • Upgrade Collective: https://www.ourupgradecollective.com [https://www.ourupgradecollective.com/]  • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]  • 40 Years of Zen: https://40yearsofzen.com [https://40yearsofzen.com/]   Timestamps:  • 0:00 Trailer  • 0:54 Intro  • 1:12 63-Second Habit Rule  • 5:14 21 vs 63 Days  • 9:20 Habits vs Trauma  • 14:19 Healing & Spiritual Insight  • 17:43 Free Will & Mind-Brain Link  • 19:11 Conscious vs Subconscious  • 26:02 Intuition & Memory  • 33:15 AI & Consciousness  • 37:56 Death & Energy  • 51:21 Forgiveness & Entanglement  • 55:14 Self-Regulation Tools  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].