This Week in Cardiology

Another negative AF ablation trial, predicting AF after stroke, the value of RCTs, troponin testing in the ED and surgical aortic valve choice are the topics John Mandrola, MD, discusses this week. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I AF ablation * Coronary Sinus Isolation for High-Burden Atrial Fibrillation: A Randomized Clinical Trial https://doi.org/10.1016/j.jacep.2024.09.017 * Approaches to Catheter Ablation for Persistent Atrial Fibrillation (STAR AFII) https://www.nejm.org/doi/full/10.1056/NEJMoa1408288 * Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial https://doi.org/10.1001/jama.2020.16195 * Hybrid Convergent Procedure for the Treatment of Persistent and Long-Standing Persistent Atrial Fibrillation: Results of CONVERGE Clinical Trial https://www.ahajournals.org/doi/10.1161/CIRCEP.120.009288 II Post-Stroke AF monitoring * Prediction of atrial fibrillation after a stroke event: a systematic review with meta-analysisMeta-analysis 10.1016/j.hrthm.2025.01.026 * Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source https://www.nejm.org/doi/full/10.1056/NEJMoa1813959 * Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source (Navigate ESUS https://www.nejm.org/doi/full/10.1056/NEJMoa1802686 * Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy (ARCADIA) https://jamanetwork.com/journals/jama/fullarticle/2814933 III RCTs * Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-025-08724-x * Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction (TASTE) https://www.nejm.org/doi/full/10.1056/NEJMoa1405707 IV Troponin Testing in the ED * Cardiac Biomarker Testing in US Emergency Departments https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2829344 * Updating Our Thinking on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967 V Choice of AVR * Bioprosthetic vs Mechanical Aortic Valve Replacement in Patients 40-75 Years https://doi.org/10.1016/j.jacc.2025.01.013 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Familial hypercholesterolemia, cardiac arrest therapy, Factor XI inhibition, and tricuspid valve interventions are the topics John Mandroa, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Familial hypercholesterolemia * Danish Registry Study: https://doi.org/10.1093/eurheartj/ehae912 II. Cardiac Arrest * Vallentin and Colleagues RCT https://www.nejm.org/doi/full/10.1056/NEJMoa2407616 III. Factor XI * AZALEA https://www.nejm.org/doi/full/10.1056/NEJMoa2406674 * OCEANIC https://www.nejm.org/doi/full/10.1056/NEJMoa2407105 * VTE Study of Abelacimab 2021 https://www.nejm.org/doi/10.1056/NEJMoa2105872 IV. Tricuspid Valve Interventions * TRILUMINATE 1-year Study https://doi.org/10.1016/j.jacc.2024.10.086 * Stone Editorial https://doi.org/10.1016/j.jacc.2024.11.045 * TRISCEND Main Paper https://www.nejm.org/doi/full/10.1056/NEJMoa2401918 * QOL Paper https://doi.org/10.1016/j.jacc.2024.10.067 * PASTE Registry https://doi.org/10.1016/j.jacc.2024.10.068 * AL-Lamee Editorial https://doi.org/10.1016/j.jacc.2024.10.085 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Renal denervation, the obesity paradox, JACC and the FINEARTS trial of finerenone in HFpEF, a setback for a PFA system, and coffee are the topics Jon Mandrola, MD, covers this week. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. RDN * CMS https://www.cms.gov/medicare-coverage-database/view/ncacal-tracking-sheet.aspx?ncaid=318 * Messerli https://doi.org/10.1016/j.jacc.2024.09.1244 * Filippone https://doi.org/10.1016/j.amjmed.2023.05.010 II. Finerenone * FINEHEARTS -HF NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2407107 * FIDELIO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2025845 * FIGARO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2110956 * Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF? https://doi.org/10.1016/j.jacc.2024.08.033 * Regional Variation TOPCAT https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255 * Time from WHF Subanalysis https://doi.org/10.1016/j.jacc.2024.09.004 * REDEFINE - https://clinicaltrials.gov/study/NCT06008197 * Health status paper https://doi.org/10.1016/j.jacc.2024.09.023 * Obesity subanalysis https://doi.org/10.1016/j.jacc.2024.10.111 * Kidney outcomes https://www.sciencedirect.com/science/article/pii/S0735109724102525 * Kidney outcomes 2 https://doi.org/10.1016/j.jacc.2024.11.020 * Kaul editorial https://doi.org/10.1016/j.jacc.2024.11.024 III. PFA Setback J&J Halts Varipulse Field Ablation for AFib https://www.medscape.com/viewarticle/j-j-halts-varipulse-field-ablation-afib-2025a10000j8 IV. Coffee Stop the Coffee Studies https://www.medscape.com/viewarticle/883709 * Coffee drinking timing and mortality in US adults  You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Alcohol and cancer, GLP-1 trial representativeness, diagnosing CAD, changing stroke rates in patients with AF, blanking periods after AF ablation are the topics John Mandrola, MD, covers this week. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Surgeon General Causes Hoopla Regarding ETOH Warning Dry January: Should Doctors Make It Year-Round? https://www.medscape.com/viewarticle/dry-january-should-doctors-make-it-year-round-2025a100009t * Surgeon General Warning https://www.hhs.gov/about/news/2025/01/03/us-surgeon-general-issues-new-advisory-link-alcohol-cancer-risk.html * GBD 2016 Collaboration Lancet https://doi.org/10.1016/S0140-6736(18)31310-2 * RCT Voskobonik and colleagues https://www.nejm.org/doi/full/10.1056/NEJMoa1817591 * Marcus and colleagues; UCSF https://pubmed.ncbi.nlm.nih.gov/33516710/ * Review of ETOH AF https://doi.org/10.1016/j.jacc.2016.08.074 II. GLP-1 Agonists for Obesity –Trial vs Real World * Generalizability of Trial Results https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2826335 * HRS Document ICD http://dx.doi.org/10.1016/j.hrthm.2014.03.041 III. Stress Testing and CAD Severity * Reynolds and colleagues. Observational ISCHEMIA Sub-analysis https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013743 * Foy Meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243 * ISCHEMIA https://www.nejm.org/doi/full/10.1056/NEJMoa1915922 IV. Changing Stroke Rates with AF * Teppo and colleagues. Finnish Study https://doi.org/10.1016/j.jacep.2024.10.029 * Quinn and colleagues. https://www.ahajournals.org/doi/10.1161/circulationaha.116.024057 V. Patients’ Lives Don’t Pause for Blanking Periods * Ruzieh and colleagues. https://doi.org/10.1016/j.ahjo.2024.100497 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Listener feedback, multiple studies in AF ablation, a DANISH trial substudy of ICDs in NICM, and more data on eye complications of GLP-1 agonists are the topics John Mandrola, MD, covers in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. CCTA Feedback * Foy meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243 * DANCAVAS https://www.nejm.org/doi/full/10.1056/NEJMoa2208681 II. Listener Feedback on my negative take of the OPTION Trial. * Option trial https://www.nejm.org/doi/pdf/10.1056/NEJMoa2408308 * My Preview https://www.medscape.com/viewarticle/mandrola-previews-option-trial-most-worrisome-study-aha-2024-2024a1000kmz * 4 Reasons to Question Percutaneous Left Atrial Appendage Closure After AF Ablation * https://www.medscape.com/viewarticle/4-reasons-question-percutaneous-left-atrial-appendage-2024a1000l0u III. AF Ablation  PVI Add-Ons Provide Better Control of Persistent AF https://www.medscape.com/viewarticle/pvi-add-ons-provide-better-control-persistent-af-2024a1000lcm * VENUS https://jamanetwork.com/journals/jama/fullarticle/2772281 * PROMPT AF https://jamanetwork.com/journals/jama/fullarticle/2826710 * STAR AF 2 https://www.nejm.org/doi/full/10.1056/NEJMoa1408288 * CRRF-PeAF https://pmc.ncbi.nlm.nih.gov/articles/PMC9241129/ * CAVAC trial https://doi.org/10.1161/CIRCEP.124.012917 * CRRF-PeAF from multiple centers in Japan (not published) IV. DANISH Trial Substudy * Danish Trial Substudy https://www.ahajournals.org/doi/epdf/10.1161/CIRCULATIONAHA.124.071777 * Danish Main https://www.nejm.org/doi/full/10.1056/NEJMoa1608029 * MADIT-2 EF Substudy https://doi.org/10.1016/S0002-9149(01)01729-5 * SCD-HeFT subgroup https://www.nejm.org/doi/full/10.1056/NEJMoa043399 * Appraisal of ICD to Prevent SCD https://doi.org/10.1016/j.jacc.2008.05.058 V. Eye disease and GLP-1 Agonists Jul 26, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001384 * Semaglutide vs No Semagutide and Eye Disease https://link.springer.com/epdf/10.1186/s40942-024-00620-x * Semaglutide vs SGLT- Inhibitors and Eye Disease https://www.medrxiv.org/content/10.1101/2024.12.09.24318574v1.full-text You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net