MedEvidence Articles

Can Clinical Trials Rise Faster Without Losing Their Flavor?

In this episode, we’re talking about the FDA’s push toward real-time clinical trials, and what that could mean for the pace, quality, and oversight of bringing new treatments to patients. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media: Facebook [https://www.facebook.com/MedEvidence] Instagram [https://www.instagram.com/med_evidence/] Twitter [https://x.com/Med_Evidence] LinkedIn [https://www.linkedin.com/company/medevidence] Tiktok [https://www.tiktok.com/@medevidence.com] Youtube [https://youtube.com/@MedEvidence] For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com [https://medevidence.com/] Thank you for listening!

What Avocados and FibroScan Teach Us About Liver Health

In this episode, we look at the need for cheap, accurate screening tools for common diseases. To that end, we take the example of fatty liver disease. We review the "gold standard" diagnostic tool, liver biopsy, and why that shouldn't be the first line of detection for a fatty liver. We review some standard methods of screening before diving into transient elastography, also known as FibroScan. We look at what this method is, why it may be preferable to an MRI or CT scan, and how clinical researchers use transient elastography in trials. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media: Facebook [https://www.facebook.com/MedEvidence] Instagram [https://www.instagram.com/med_evidence/] Twitter [https://x.com/Med_Evidence] LinkedIn [https://www.linkedin.com/company/medevidence] Tiktok [https://www.tiktok.com/@medevidence.com] Youtube [https://youtube.com/@MedEvidence] For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com [https://medevidence.com/] Thank you for listening!

The Mental and Physical Toll of PCOS

In this week's episode, guest author Maya Yanchuck explores the ins and outs of PCOS. We review what the condition is, symptoms, complications, and what is happening in the body. Finally, we look at treatments, from mental health to medicaitons. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media: Facebook [https://www.facebook.com/MedEvidence] Instagram [https://www.instagram.com/med_evidence/] Twitter [https://x.com/Med_Evidence] LinkedIn [https://www.linkedin.com/company/medevidence] Tiktok [https://www.tiktok.com/@medevidence.com] Youtube [https://youtube.com/@MedEvidence] For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com [https://medevidence.com/] Thank you for listening!

The Brain’s Hidden Vulnerability: How Misinformation Rewires What We Believe

In this week's episode, written by guest author Christy Kestner, we explore the neuroscience of misinformation. We look inot what misinformation is, what happens inside the brain when we encounter misinformation, why misinformation can be so hard to correct, and some of the real-life consequences with misinformation - especialyl in relation to health. We close by discussing how we can combat misinformation, from correcting false ideas to protecting against inflammatory, misleading informaiton found online. References: * Bragazzi NL, Garbarino S. Understanding and combating misinformation: An evolutionary perspective. JMIR infodemiology. 2024 Dec 27;4(1):e65521. https://doi.org/10.2196/65521 [https://doi.org/10.2196/65521] * Piksa M, Noworyta K, Gundersen A, Kunst J, Morzy M, Piasecki J, Rygula R. The impact of confirmation bias awareness on mitigating susceptibility to misinformation. Frontiers in Public Health. 2024 Oct 15;12:1414864. https://doi.org/10.3389/fpubh.2024.1414864 [https://doi.org/10.3389/fpubh.2024.1414864] * Hassan A, Barber SJ. The effects of repetition frequency on the illusory truth effect. Cognitive research: principles and implications. 2021 May 13;6(1):38. https://doi.org/10.1186/s41235-021-00301-5 [https://doi.org/10.1186/s41235-021-00301-5] * Schultz W. Dopamine reward prediction error coding. Dialogues in clinical neuroscience. 2016 Mar 31;18(1):23-32. https://doi.org/10.31887/DCNS.2016.18.1/wschultz [https://doi.org/10.31887/DCNS.2016.18.1/wschultz] * Chau LS, Galvez R. Amygdala's involvement in facilitating associative learning-induced plasticity: a promiscuous role for the amygdala in memory acquisition. Frontiers in integrative neuroscience. 2012 Oct 10;6:92. https://doi.org/10.3389/fnint.2012.00092 [https://doi.org/10.3389/fnint.2012.00092] * Vellani V, Zheng S, Ercelik D, Sharot T. The illusory truth effect leads to the spread of misinformation. Cognition. 2023 Jul 1;236:105421. https://doi.org/10.1016/j.cognition.2023.105421 [https://doi.org/10.1016/j.cognition.2023.105421] * Chan MP, Jones CR, Hall Jamieson K, Albarracín D. Debunking: A meta-analysis of the psychological efficacy of messages countering misinformation. Psychological science. 2017 Nov;28(11):1531-46. https://doi.org/10.1177/0956797617714579 [https://doi.org/10.1177/0956797617714579] Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media: Facebook [https://www.facebook.com/MedEvidence] Instagram [https://www.instagram.com/med_evidence/] Twitter [https://x.com/Med_Evidence] LinkedIn [https://www.linkedin.com/company/medevidence] Tiktok [https://www.tiktok.com/@medevidence.com] Youtube [https://youtube.com/@MedEvidence] For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com [https://medevidence.com/] Thank you for listening!

Degenerative Joint Disease is Your Body's Squeaky Wheel

In this week's episode, we explore the most common type of degenerative joint disease, osteoarthritis. We look at the risks of getting the disease, complications and symptoms, and what can be done about it. We also look at what may be next on the horizon; clinical trials targeting degenerative joint disease in myriad ways. References: * Murphy L, Schwartz TA, Helmick CG, Renner JB, Tudor G, Koch G, Dragomir A, Kalsbeek WD, Luta G, Jordan JM. Lifetime risk of symptomatic knee osteoarthritis. Arthritis Care & Research: Official Journal of the American College of Rheumatology. 2008 Sep 15;59(9):1207-13. https://doi.org/10.1002/art.24021 [https://doi.org/10.1002/art.24021] * Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthritis and cartilage. 2022 Feb 1;30(2):184-95. https://doi.org/10.1016/j.joca.2021.04.020 [https://doi.org/10.1016/j.joca.2021.04.020] * Mobasheri A, Batt M. An update on the pathophysiology of osteoarthritis. Annals of physical and rehabilitation medicine. 2016 Dec 1;59(5-6):333-9. https://doi.org/10.1016/j.rehab.2016.07.004 [https://doi.org/10.1016/j.rehab.2016.07.004] * Fusco M, Skaper SD, Coaccioli S, Varrassi G, Paladini A. Degenerative joint diseases and neuroinflammation. Pain Practice. 2017 Apr;17(4):522-32. https://doi.org/10.1111/papr.12551 [https://doi.org/10.1111/papr.12551] * Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, Gellar K. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis & rheumatology. 2020 Feb;72(2):220-33. https://doi.org/10.1002/acr.24131 [https://doi.org/10.1002/acr.24131] Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media: Facebook [https://www.facebook.com/MedEvidence] Instagram [https://www.instagram.com/med_evidence/] Twitter [https://x.com/Med_Evidence] LinkedIn [https://www.linkedin.com/company/medevidence] Tiktok [https://www.tiktok.com/@medevidence.com] Youtube [https://youtube.com/@MedEvidence] For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com [https://medevidence.com/] Thank you for listening!