Decoding Longevity

Resetting Cells Without Rewinding Identity: A Conversation with Janine Sengstack, Ph.D.

Can aging cells be reset — without turning them into stem cells? In Episode 26 of Decoding Longevity, Dr. Janine Sengstack explains how Genevity is using AI, human data, and RNA therapeutics to identify the master regulators of aging and restore cells to healthier states. This episode explores the intersection of aging biology, transcription factors, siRNA therapeutics, and precision longevity medicine. 🔗 Junevity: https://www.junevity.com/

Redesigning Aging: Ethics, Economics, and the Narrative of Longevity — A Conversation with Raiany Romanni-Klein, Ph.D.

What if the biggest barrier to healthy longevity isn’t scientific—but philosophical, economic, and ethical? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques are joined by Dr. Raiany Romanni-Klein to explore how our beliefs about aging, death, and human value shape the future of longevity science. From the idea that “natural is good” to the economic incentives holding the field back, this conversation challenges how we think about aging—and what it will take to change it. 🔗 Resources & Links: * Silver Linings : https://silverlinings.bio/ * Raiany’s TEDx Talk: https://www.youtube.com/watch?v=kB1IFGYaYXo

The First Cellular Rejuvenation Therapy in Clinical Trials with Michael Ringel, Ph.D., J.D.

Aging might not be inevitable. In this episode of Decoding Longevity, Dr. Michael Ringel (COO, Life Biosciences) explains how scientists are learning to “reset” the biological age of cells—without changing what they are. From reversing vision loss in preclinical models to launching one of the first human trials, this conversation explores a future where we don’t just treat diseases of aging—we target aging itself. 🔗 Show notes: * Life Biosciences: https://www.lifebiosciences.com/ * Clinical pipeline: https://www.lifebiosciences.com/pipeline/ * Michael Ringel talks: https://www.youtube.com/watch?v=XC31N9KbOEs / https://www.youtube.com/watch?v=OycGR-03S8A / https://www.youtube.com/watch?v=EZUBjXv5wIw

Mobility, Metabolism, and Resilience: Translating Geroscience into Function — A Conversation with Steve Kritchevsky

What if aging isn’t defined by disease — but by how much function we preserve over time? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques sit down with Stephen Kritchevsky to explore how mobility, metabolism, and physiological resilience shape the aging process. From walking speed as a powerful integrative biomarker… to why muscle quality may matter more than muscle mass… to what long-term trials like Look AHEAD reveal about bending aging trajectories — this conversation reframes longevity around function, not just lifespan. We also dive into the trade-offs of weight loss in older adults, the connection between brain and physical aging, and what it will take to measure — and truly slow — aging in humans.

From Science to Strategy: How Policy Will Shape the Future of Longevity — A Conversation with Dylan Livingston

What if the biggest barrier to extending healthy human lifespan isn’t the science — but policy? In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques speak with Dylan Livingston, founder of the Alliance for Longevity Initiatives. Together, they explore why public policy may be one of the most important — and overlooked — drivers of progress in longevity science. From building support for aging research funding to launching the Congressional Longevity Science Caucus and expanding access to investigational therapies, Dylan shares how advocacy and legislation could shape the future of preventative medicine and healthy aging. Learn more: Alliance for Longevity Initiatives (A4LI) → https://a4li.org/ LongeviPAC → https://www.longevipac.org/