JAMA Clinical Reviews

Restless Legs Syndrome

Restless legs syndrome is a sleep-related neurologic disorder that causes an overwhelming urge to move the limbs, which can cause substantial sleep disturbance. Author John W. Winkelman, MD, PhD, of Harvard Medical School joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the symptoms, risk factors, diagnosis, and treatment of restless legs syndrome. Related Content: * Restless Legs Syndrome [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.23247?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links]

A Conversation About the FDA's Regulation of Mifepristone

Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration (FDA). Author G. Caleb Alexander, MD, MS, from Johns Hopkins discusses this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS. Related Content: * The US Food and Drug Administration's Regulation of Mifepristone [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.23091?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Politics, Science, and the Future of FDA Drug Regulation [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.24868?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links]

Gastric Cancer Worldwide

Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide. JAMA Review author Haeseong Park, MD, MPH, from the Dana Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content: * Gastric Cancer [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.20034?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links]

JAMA Editors' Choice 2025: Clinical Reviews Podcasts

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts in 2025. Related Content: * Managing Adverse Effects of Obesity Medications [https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2025.12573?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Diagnosis and Management of Hypothyroidism [https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2025.14083?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment [https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2025.7932?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Managing Adverse Effects of Incretin-Based Medications for Obesity [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.11153?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Hypothyroidism [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.13559?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Diagnosis and Treatment of Type 2 Diabetes in Adults [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.5956?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * JAMA Editors' Choice 2024: Clinical Reviews Podcasts [https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2024.27899?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links]

From the JAMA Network: JAMA Research of the Year With Editor in Chief Kirsten Bibbins-Domingo

In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup. Related Content: * Research of the Year 2025 [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.20503?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links]