Medscape InDiscussion: Systemic Lupus Erythematosus

SLE and Reproductive Health: Navigating Risks and Options

Dr Lisa Sammaritano shares evidence-based strategies for pregnancy planning, contraception, and reproductive counseling in women with systemic lupus erythematosus. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002129. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases https://pubmed.ncbi.nlm.nih.gov/32090480/ EULAR Recommendations for Use of Antirheumatic Drugs in Reproduction, Pregnancy, and Lactation: 2024 Update https://pubmed.ncbi.nlm.nih.gov/40287311/ Contraception in Patients With Rheumatic Disease https://pubmed.ncbi.nlm.nih.gov/28390561/ Combined Oral Contraceptives in Women With Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/16354891/ Pregnancy Outcomes Between Pregnant Systemic Lupus Erythematosus Patients With Clinical Remission and Those With Low Disease Activity: A Comparative Study https://pubmed.ncbi.nlm.nih.gov/36589601/ Prevention of Preeclampsia With Aspirin https://pubmed.ncbi.nlm.nih.gov/32835720/ Adverse Effects of Prenatal Dexamethasone Exposure on Fetal Development https://pubmed.ncbi.nlm.nih.gov/35367871/ Prospective Evaluation of High Titer Autoantibodies and Fetal Home Monitoring in the Detection of Atrioventricular Block Among Anti-SSA/Ro Pregnancies https://pubmed.ncbi.nlm.nih.gov/37947364/ The Effect of Combined Estrogen and Progesterone Hormone Replacement Therapy on Disease Activity in Systemic Lupus Erythematosus: A Randomized Trial https://pubmed.ncbi.nlm.nih.gov/15968009/ Fezolinetant Prescribing Information https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/216578s000lbl.pdf

Lupus Rashes: What to Spot, What to Shield

From subtle rashes to sun-safety strategies, Drs Maureen McMahon and John Edminister discuss how to recognize cutaneous lupus and protect patients from UV-triggered flares. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002128. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/31385462/ Interface Dermatitis: Delineating the Diagnosis With Adaptive Immune Markers https://pubmed.ncbi.nlm.nih.gov/35355305/ Rowell Syndrome: A Controversial Entity https://pubmed.ncbi.nlm.nih.gov/40369729/ Subtype and Racial Erythema Variation for Cutaneous Lupus Trials https://pubmed.ncbi.nlm.nih.gov/39630477/ Integrating Skin Color Assessments Into Clinical Practice and Research: A Review of Current Approaches https://pubmed.ncbi.nlm.nih.gov/38342247/ Overview on Desonide 0.05%: A Clinical Safety Profile https://pubmed.ncbi.nlm.nih.gov/15303783/ Efficacy of Topical Tacrolimus for Treating the Malar Rash of Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/12588393/ Cicatricial Alopecia: Discoid Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/18715293/ Fluocinolone Acetonide Topical Oil for Scalp Psoriasis https://pubmed.ncbi.nlm.nih.gov/15764047/ Early Initiation of Hydroxychloroquine in Cutaneous Lupus Erythematosus to Prevent Progression to Systemic Lupus Erythematosus: A Long-Term Follow-Up Study https://pubmed.ncbi.nlm.nih.gov/40015570/ The Autoantibody Response to Ro/SSA in Cutaneous Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/7944507/ Monitoring for Retinal Toxicity in Patients Taking Hydroxychloroquine and Chloroquine https://pubmed.ncbi.nlm.nih.gov/29529306/

Lupus and Lifestyle: What Patients Can Control

Join Drs Maureen McMahon and Karen Costenbader as they explore how diet, pollution, infections, and lifestyle factors influence lupus risk and what patients can do about it. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002127. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Systemic Lupus Erythematosus (SLE) https://emedicine.medscape.com/article/332244-overview Risk Prediction Models for Incident Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts Using Genetics, Family History, and Lifestyle and Environmental Factors https://pubmed.ncbi.nlm.nih.gov/36481507/ Association of Macronutrients and Dietary Patterns With Risk of Systemic Lupus Erythematosus in the Black Women's Health Study https://pubmed.ncbi.nlm.nih.gov/34225359/ Dietary Patterns and Risk of Systemic Lupus Erythematosus in Women https://pubmed.ncbi.nlm.nih.gov/31718449/ Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease https://pubmed.ncbi.nlm.nih.gov/22513989/ Ultra-Processed Foods: What They Are and How to Identify Them https://pubmed.ncbi.nlm.nih.gov/30744710/ Anti-dsDNA Antibodies in the Classification Criteria of Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/35028552/ Identifying and Estimating Ultraprocessed Food Intake in the US NHANES According to the Nova Classification System of Food Processing https://pubmed.ncbi.nlm.nih.gov/36913457/ Development of a Predictive Model for Systemic Lupus Erythematosus Incidence Risk Based on Environmental Exposure Factors https://pubmed.ncbi.nlm.nih.gov/39572059/ Systemic Autoimmune Rheumatic Diseases and Multiple Industrial Air Pollutant Emissions: A Large General Population Canadian Cohort Analysis https://pubmed.ncbi.nlm.nih.gov/37068387/ Pesticide Exposure and Risk of Rheumatoid Arthritis Among Licensed Male Pesticide Applicators in the Agricultural Health Study https://pubmed.ncbi.nlm.nih.gov/28718769/ Pesticide Exposure and Risk of Systemic Lupus Erythematosus in an Urban Population of Predominantly African-American Women https://pubmed.ncbi.nlm.nih.gov/30309287/ Association of Sleep Deprivation and the Risk of Developing Systemic Lupus Erythematosus Among Women https://pubmed.ncbi.nlm.nih.gov/36094865/

In Lupus, How to Spot Hidden Heart Risk

Join Drs Maureen McMahon and Michael Garshick as they discuss cardiovascular disease in patients with systemic lupus erythematosus, focusing on hidden risk and challenging clinical scenarios. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002126. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Systemic Lupus Erythematosus (SLE) https://emedicine.medscape.com/article/332244-overview Sore, Hot, and At Risk: The Emerging Specialty of Cardio-Rheumatology https://pubmed.ncbi.nlm.nih.gov/37232258/ The Bimodal Mortality Pattern of Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/1251849/ About CDC-Funded Lupus Research https://www.cdc.gov/lupus/php/surveillance/index.html Traditional Framingham Risk Factors Fail to Fully Account for Accelerated Atherosclerosis in Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/11665973/ Publisher Correction: Efferocytosis Drives a Tryptophan Metabolism Pathway in Macrophages to Promote Tissue Resolution https://pubmed.ncbi.nlm.nih.gov/39285251/ Cholesterol Efflux Pathways, Inflammation, and Atherosclerosis https://pubmed.ncbi.nlm.nih.gov/34182846/ Role of Coronary Artery Calcium Score in the Primary Prevention of Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/33947652/ Evaluation of Intima-Media Thickness and Arterial Stiffness as Early Ultrasound Biomarkers of Carotid Artery Atherosclerosis https://pubmed.ncbi.nlm.nih.gov/35362868/ Lupus Atherosclerosis Prevention Study (LAPS) https://pubmed.ncbi.nlm.nih.gov/21177297/ Colchicine in Acute Myocardial Infarction - CLEAR SYNERGY (OASIS 9) Colchicine https://www.acc.org/latest-in-cardiology/clinical-trials/2024/10/25/04/34/clear-synergy

New Guidelines and the Lupus Nephritis Kidney Conundrum

Join Drs Maureen McMahon and Brad Rovin as they discuss the KDIGO, ACR and EULAR guidelines as they relate to lupus nephritis. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002125. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources 2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis https://rheumatology.org/press-releases/new-acr-guideline-summary-provides-guidance-to-screen-treat-and-manage-lupus-nephritis KDIGO 2024 Clinical Practice Guideline for the Management of Lupus Nephritis https://pubmed.ncbi.nlm.nih.gov/38182286/ EULAR 2023 Recommendations for SLE Treatment: Synopsis for the Management of Lupus Nephritis: The European Renal Association-Immunonephrology Working Group (ERA-IWG) Perspective https://pubmed.ncbi.nlm.nih.gov/37881002/ Efficacy and Safety of Voclosporin Versus Placebo for Lupus Nephritis (AURORA 1): A Double-Blind, Randomised, Multicentre, Placebo-Controlled, Phase 3 Trial https://pubmed.ncbi.nlm.nih.gov/33971155/ Podocytes https://pubmed.ncbi.nlm.nih.gov/26918173/ Can Podocytes Be Regenerated in Adults? https://pubmed.ncbi.nlm.nih.gov/28306565/ Prospective Observational Single-Centre Cohort Study to Evaluate the Effectiveness of Treating Lupus Nephritis With Rituximab and Mycophenolate Mofetil but No Oral Steroids https://pubmed.ncbi.nlm.nih.gov/23740227/ Safety of Kidney Biopsy When Performed as an Outpatient Procedure https://pubmed.ncbi.nlm.nih.gov/34077930/ Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis https://pubmed.ncbi.nlm.nih.gov/39927615/ Anifrolumab in Lupus Nephritis: Results From Second-Year Extension of a Randomised Phase II Trial https://pubmed.ncbi.nlm.nih.gov/37607780/