JAMA Clinical Reviews

Geroscience aims to define and modify biologic pathways associated with aging and age-related diseases. Author Stephen B. Kritchevsky, PhD, of the Wake Forest University School of Medicine and JAMA Deputy Editor Mary M. McDermott, MD, discuss current evidence regarding geroscience, human health, and promising therapies that may slow aging and age-related decline. Related Content: * Geroscience [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.11289?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] ----------------------------------- JAMA Editors' Summary [https://jamanetwork.com/journals/jama/pages/jama-editors-summary?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=2507-jcr-podcastpreroll]

New medications for obesity, such as semaglutide and tirzepatide, are highly effective but can be associated with adverse effects that reduce adherence. Obesity expert and author Robert Kushner, MD, joins JAMA Deputy Editor Mary McDermott, MD, to discuss a recent JAMA Insights article on managing adverse effects of obesity medications. Related Content: * Managing Adverse Effects of Incretin-Based Medications for Obesity [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.11153?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] ----------------------------------- JAMA Editors' Summary [https://jamanetwork.com/journals/jama/pages/jama-editors-summary?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=2507-jcr-podcastpreroll]

A patent foramen ovale (PFO) is present in approximately 25% of all adults. Author David M. Kent, MD, MS, of Tufts Medical Center and JAMA Associate Editor David Simel, MD, MHS, discuss how to evaluate the likelihood that a PFO was causal in a patient with a cryptogenic ischemic stroke, and closure of a PFO to lower the incidence of recurrent strokes for affected patients. Related Content: * Patent Foramen Ovale and Stroke [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.10946?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Patent Foramen Ovale and Dysarthria in a Man in His 60s [https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2025.1679?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2020.22176?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2021.20956?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Transesophageal Echocardiogram Detecting a High-Risk Patent Foramen Ovale [https://edhub.ama-assn.org/jn-learning/video-player/10.1001/jama.2025.11698?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] ----------------------------------- JAMA Editors' Summary [https://jamanetwork.com/journals/jama/pages/jama-editors-summary?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=2507-jcr-podcastpreroll]

Approximately 200 000 people are hospitalized for diverticulitis each year in the US, and the incidence of diverticulitis is increasing, particularly among younger people. Author Anthony Charles, MD, MPH, of the University of Vermont and JAMA Deputy Editor Mary M. McDermott, MD, discuss current evidence regarding the epidemiology, diagnosis, and treatment of diverticulitis. Related Content: * Diverticulitis [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.10234?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Quality-of-Life and Recurrence Outcomes Following Laparoscopic Elective Sigmoid Resection vs Conservative Treatment Following Diverticulitis [https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2023.0466?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Racial and Ethnic Disparities in Locoregional Recurrence Among Patients With Hormone Receptor–Positive, Node-Negative Breast Cancer [https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2023.0297?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] ----------------------------------- JAMA Editors' Summary [https://jamanetwork.com/journals/jama/pages/jama-editors-summary?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=2507-jcr-podcastpreroll]

A recent Review discusses the epidemiology, risk factors, diagnosis, and treatment of ovarian cancer. William Cliby, MD, and John Weroha, MD, PhD, both from the Mayo Clinic in Rochester, Minnesota, discuss this and more with JAMA Associate Editor Margaret Wheeler, MD. Related Content: * Ovarian Cancer [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.9495?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Endometriosis Typology and Ovarian Cancer Risk [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.9210?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] * Screening for Ovarian Cancer [https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2017.21926?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=related_article_links] ----------------------------------- JAMA Editors' Summary [https://jamanetwork.com/journals/jama/pages/jama-editors-summary?utm_source=podcast_platforms&utm_medium=referral&utm_campaign=2507-jcr-podcastpreroll]